Mathematical Modeling of the Adaptive Immune Responses in the Early Stage of the HBV Infection

Karam Allali, Adil Meskaf, Abdessamad Tridane

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The aim of this paper is to study the early stage of HBV infection and impact delay in the infection process on the adaptive immune response, which includes cytotoxic T-lymphocytes and antibodies. In this stage, the growth of the healthy hepatocyte cells is logistic while the growth of the infected ones is linear. To investigate the role of the treatment at this stage, we also consider two types of treatment: interferon- (IFN) and nucleoside analogues (NAs). To find the best strategy to use this treatment, an optimal control approach is developed to find the possibility of having a functional cure to HBV.

Original languageEnglish
Article number6710575
JournalInternational Journal of Differential Equations
Volume2018
DOIs
Publication statusPublished - 2018

ASJC Scopus subject areas

  • Analysis
  • Applied Mathematics

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