TY - JOUR
T1 - Mathematical Modeling of the Adaptive Immune Responses in the Early Stage of the HBV Infection
AU - Allali, Karam
AU - Meskaf, Adil
AU - Tridane, Abdessamad
N1 - Publisher Copyright:
© 2018 Karam Allali et al.
PY - 2018
Y1 - 2018
N2 - The aim of this paper is to study the early stage of HBV infection and impact delay in the infection process on the adaptive immune response, which includes cytotoxic T-lymphocytes and antibodies. In this stage, the growth of the healthy hepatocyte cells is logistic while the growth of the infected ones is linear. To investigate the role of the treatment at this stage, we also consider two types of treatment: interferon- (IFN) and nucleoside analogues (NAs). To find the best strategy to use this treatment, an optimal control approach is developed to find the possibility of having a functional cure to HBV.
AB - The aim of this paper is to study the early stage of HBV infection and impact delay in the infection process on the adaptive immune response, which includes cytotoxic T-lymphocytes and antibodies. In this stage, the growth of the healthy hepatocyte cells is logistic while the growth of the infected ones is linear. To investigate the role of the treatment at this stage, we also consider two types of treatment: interferon- (IFN) and nucleoside analogues (NAs). To find the best strategy to use this treatment, an optimal control approach is developed to find the possibility of having a functional cure to HBV.
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U2 - 10.1155/2018/6710575
DO - 10.1155/2018/6710575
M3 - Article
AN - SCOPUS:85042156190
SN - 1687-9643
VL - 2018
JO - International Journal of Differential Equations
JF - International Journal of Differential Equations
M1 - 6710575
ER -