Mechanisms underlying electro-mechanical dysfunction in the Zucker diabetic fatty rat heart: a model of obesity and type 2 diabetes

Ahmed Sultan, Jaipaul Singh, Frank Christopher Howarth

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Diabetes mellitus (DM) is a major and worsening global health problem, currently affecting over 450 million people and reducing their quality of life. Type 2 diabetes mellitus (T2DM) accounts for more than 90% of DM and the global epidemic of obesity, which largely explains the dramatic increase in the incidence and prevalence of T2DM in the past 20 years. Obesity is a major risk factor for DM which is a major cause of morbidity and mortality in diabetic patients. The electro-mechanical function of the heart is frequently compromised in diabetic patients. The aim of this review is to discuss the pathophysiology of electro-mechanical dysfunction in the diabetic heart and in particular, the Zucker diabetic fatty (ZDF) rat heart, a well-studied model of T2DM and obesity.

Original languageEnglish
Pages (from-to)873-886
Number of pages14
JournalHeart Failure Reviews
Volume25
Issue number5
DOIs
Publication statusPublished - Sept 1 2020

Keywords

  • Diabetes
  • Electro-mechanical function of the heart
  • Heart
  • Obesity
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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