Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy

Ali Al-Samydai, Hamdi Nsairat, Maha N. Abu Hajleh, Bayan Aburas, Amal Akour, Tha’er Husam Ata, Tabarek H. Mahmood, Tabarak Riyadh Al-sammarraie, Rawan Atta, Rahaf Ali, Qasim Khalid Alazzawi, Ahmed Aburjai, Simone Carradori

Research output: Contribution to journalArticlepeer-review


Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability and therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) and IC50 values were investigated. Multivariate Analysis of Covariance revealed significant phytochemicals type effects, even when accounting for cancer cell type and phospholipid type as covariates. Least Significant Difference (LSD) post hoc tests described unique attributes among various phytosomes. Flavonoid-based phytosomes exhibited larger particle sizes than others. In contrast, terpenoid-based phytosomes displayed significantly lower charges. Flavonoids demonstrated higher poly dispersity index (PDI) values than alkaloids and polyphenols. Alkaloids exhibited more extensive PDI values, while polyphenols had lower PDI values than terpenoids. Furthermore, flavonoid-containing nanoparticles exhibited higher IC50 values than terpenoids. In conclusion, nano-phytosomes offer promising prospects for revolutionising drug delivery methodologies and advancing the development of innovative therapeutic solutions in the domain of cancer therapy.

Original languageEnglish
JournalNatural Product Research
Publication statusAccepted/In press - 2024


  • Alkaloids
  • cancer
  • flavonoids
  • nano-phytosomes
  • nanotechnology
  • polyphenols
  • terpenoids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry


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