Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy

Ali Al-Samydai; Hamdi Nsairat; Maha N. Abu Hajleh; Bayan Aburas; Amal Akour; Tha’er Husam Ata; Tabarek H. Mahmood; Tabarak Riyadh Al-sammarraie; Rawan Atta; Rahaf Ali; Qasim Khalid Alazzawi; Ahmed Aburjai; Simone Carradori

doi:10.1080/14786419.2024.2344182

Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy

Ali Al-Samydai, Hamdi Nsairat, Maha N. Abu Hajleh, Bayan Aburas, Amal Akour, Tha’er Husam Ata, Tabarek H. Mahmood, Tabarak Riyadh Al-sammarraie, Rawan Atta, Rahaf Ali, Qasim Khalid Alazzawi, Ahmed Aburjai, Simone Carradori

Department of Pharmacology and Therapeutics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability and therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) and IC₅₀ values were investigated. Multivariate Analysis of Covariance revealed significant phytochemicals type effects, even when accounting for cancer cell type and phospholipid type as covariates. Least Significant Difference (LSD) post hoc tests described unique attributes among various phytosomes. Flavonoid-based phytosomes exhibited larger particle sizes than others. In contrast, terpenoid-based phytosomes displayed significantly lower charges. Flavonoids demonstrated higher poly dispersity index (PDI) values than alkaloids and polyphenols. Alkaloids exhibited more extensive PDI values, while polyphenols had lower PDI values than terpenoids. Furthermore, flavonoid-containing nanoparticles exhibited higher IC₅₀ values than terpenoids. In conclusion, nano-phytosomes offer promising prospects for revolutionising drug delivery methodologies and advancing the development of innovative therapeutic solutions in the domain of cancer therapy.

Original language	English
Journal	Natural Product Research
DOIs	https://doi.org/10.1080/14786419.2024.2344182
Publication status	Accepted/In press - 2024

Keywords

Alkaloids
cancer
flavonoids
nano-phytosomes
nanotechnology
polyphenols
terpenoids

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14786419.2024.2344182

Cite this

Al-Samydai, A., Nsairat, H., Abu Hajleh, M. N., Aburas, B., Akour, A., Ata, T. H., Mahmood, T. H., Al-sammarraie, T. R., Atta, R., Ali, R., Alazzawi, Q. K., Aburjai, A., & Carradori, S. (Accepted/In press). Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy. Natural Product Research. https://doi.org/10.1080/14786419.2024.2344182

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abstract = "Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability and therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) and IC50 values were investigated. Multivariate Analysis of Covariance revealed significant phytochemicals type effects, even when accounting for cancer cell type and phospholipid type as covariates. Least Significant Difference (LSD) post hoc tests described unique attributes among various phytosomes. Flavonoid-based phytosomes exhibited larger particle sizes than others. In contrast, terpenoid-based phytosomes displayed significantly lower charges. Flavonoids demonstrated higher poly dispersity index (PDI) values than alkaloids and polyphenols. Alkaloids exhibited more extensive PDI values, while polyphenols had lower PDI values than terpenoids. Furthermore, flavonoid-containing nanoparticles exhibited higher IC50 values than terpenoids. In conclusion, nano-phytosomes offer promising prospects for revolutionising drug delivery methodologies and advancing the development of innovative therapeutic solutions in the domain of cancer therapy.",

keywords = "Alkaloids, cancer, flavonoids, nano-phytosomes, nanotechnology, polyphenols, terpenoids",

author = "Ali Al-Samydai and Hamdi Nsairat and {Abu Hajleh}, {Maha N.} and Bayan Aburas and Amal Akour and Ata, {Tha{\textquoteright}er Husam} and Mahmood, {Tabarek H.} and Al-sammarraie, {Tabarak Riyadh} and Rawan Atta and Rahaf Ali and Alazzawi, {Qasim Khalid} and Ahmed Aburjai and Simone Carradori",

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year = "2024",

doi = "10.1080/14786419.2024.2344182",

language = "English",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor and Francis Ltd.",

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T2 - unleashing the potential of plant-derived compounds for advancing cancer therapy

AU - Al-Samydai, Ali

AU - Nsairat, Hamdi

AU - Abu Hajleh, Maha N.

AU - Aburas, Bayan

AU - Akour, Amal

AU - Ata, Tha’er Husam

AU - Mahmood, Tabarek H.

AU - Al-sammarraie, Tabarak Riyadh

AU - Atta, Rawan

AU - Ali, Rahaf

AU - Alazzawi, Qasim Khalid

AU - Aburjai, Ahmed

AU - Carradori, Simone

PY - 2024

Y1 - 2024

N2 - Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability and therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) and IC50 values were investigated. Multivariate Analysis of Covariance revealed significant phytochemicals type effects, even when accounting for cancer cell type and phospholipid type as covariates. Least Significant Difference (LSD) post hoc tests described unique attributes among various phytosomes. Flavonoid-based phytosomes exhibited larger particle sizes than others. In contrast, terpenoid-based phytosomes displayed significantly lower charges. Flavonoids demonstrated higher poly dispersity index (PDI) values than alkaloids and polyphenols. Alkaloids exhibited more extensive PDI values, while polyphenols had lower PDI values than terpenoids. Furthermore, flavonoid-containing nanoparticles exhibited higher IC50 values than terpenoids. In conclusion, nano-phytosomes offer promising prospects for revolutionising drug delivery methodologies and advancing the development of innovative therapeutic solutions in the domain of cancer therapy.

AB - Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability and therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) and IC50 values were investigated. Multivariate Analysis of Covariance revealed significant phytochemicals type effects, even when accounting for cancer cell type and phospholipid type as covariates. Least Significant Difference (LSD) post hoc tests described unique attributes among various phytosomes. Flavonoid-based phytosomes exhibited larger particle sizes than others. In contrast, terpenoid-based phytosomes displayed significantly lower charges. Flavonoids demonstrated higher poly dispersity index (PDI) values than alkaloids and polyphenols. Alkaloids exhibited more extensive PDI values, while polyphenols had lower PDI values than terpenoids. Furthermore, flavonoid-containing nanoparticles exhibited higher IC50 values than terpenoids. In conclusion, nano-phytosomes offer promising prospects for revolutionising drug delivery methodologies and advancing the development of innovative therapeutic solutions in the domain of cancer therapy.

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KW - cancer

KW - flavonoids

KW - nano-phytosomes

KW - nanotechnology

KW - polyphenols

KW - terpenoids

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Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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