Metaanálisis de estudios sobre resonancia magnética del cuerpo calloso en la esquizofrenia

Translated title of the contribution: Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia

D. Arnone, A. M. McIntosh, G. M.Y. Tan, K. P. Ebmeier

Research output: Contribution to journalArticlepeer-review


Objectives: The corpus callosum plays a pivotal role in inter-hemispheric transfer and integration of information. Magnetic resonance studies have reported callosal abnormalities in schizophrenia but findings have been inconsistent. Uncertainty has persisted despite a meta-analytic evaluation of this structure several years ago. We set out to perform a further meta-analysis with the addition of the numerous reports published on the subject to test the hypothesis that the corpus callosum is abnormal in schizophrenia. Method: A systematic search was carried out to identify suitable magnetic resonance studies which reported callosal areas in schizophrenia compared to controls. Results from the retrieved studies were compared in a meta-analysis whilst the influence of biological and clinical variables on effect size was ascertained with meta-regression analysis. Results: Twenty-eight studies were identified. Corpus callosum area was reduced in schizophrenia in comparison to healthy volunteers. This effect was larger in first episode patients. similarly, heterogeneity detected among the studies was associated with course of illness indicating that chronic subjects with schizophrenia showed larger callosal areas. There was no evidence of publication bias. CONCLUsIONs: This study confirms the presence of reduced callosal areas in schizophrenia. The effect is of a larger magnitude at first presentation and less so in subjects with a chronic course generally medicated with antipsychotics.

Translated title of the contributionMeta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia
Original languageSpanish
Pages (from-to)214-222
Number of pages9
JournalPsiquiatria Biologica
Issue number6
Publication statusPublished - Nov 2008
Externally publishedYes


  • Corpus callosum
  • Magnetic resonance imaging
  • Neuroimaging
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health


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