TY - JOUR
T1 - Metabolomics approach for the identification of bioactive compounds released from young and mature soybean upon in vitro gastrointestinal digestion and their effect on health-related bioactive properties
AU - Ajayi, Feyisola Fisayo
AU - Alnuaimi, Amna
AU - Hamdi, Marwa
AU - Mostafa, Hussein
AU - Wakayama, Masataka
AU - Mudgil, Priti
AU - Maqsood, Sajid
N1 - Funding Information:
Authors would like to thank United Arab Emirates University for providing funding support for this study through a research grant 12F002.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/9/15
Y1 - 2023/9/15
N2 - The aim of the present study was to comparatively investigate the relative phytochemical profiles (phenolic content, organic and amino acids, free sugars, and other metabolites using metabolomics approach), and bioactive potentials of young (YS) and mature soybean (MS) upon in vitro simulated gastrointestinal digestion (SGID). Cumulatively, a total of 198 metabolites were identified in MS and YS, 119 metabolites in undigested YS, and a total of 136 metabolites in undigested MS, which further increased to 156 and 152 in YS and MS upon SGID, respectively. Gastric digesta of both YS and MS exhibited higher inhibitory properties towards α-amylase and DPP-IV enzymes than their intestinal digesta. Furthermore, the intestinal digesta of MS showed higher antioxidant and anti-inflammatory activities compared to the YS intestinal digesta. Overall, the results suggested that the gastrointestinal digestion of YS and MS displayed distinctive metabolic profiles together with varied bioactive potentials.
AB - The aim of the present study was to comparatively investigate the relative phytochemical profiles (phenolic content, organic and amino acids, free sugars, and other metabolites using metabolomics approach), and bioactive potentials of young (YS) and mature soybean (MS) upon in vitro simulated gastrointestinal digestion (SGID). Cumulatively, a total of 198 metabolites were identified in MS and YS, 119 metabolites in undigested YS, and a total of 136 metabolites in undigested MS, which further increased to 156 and 152 in YS and MS upon SGID, respectively. Gastric digesta of both YS and MS exhibited higher inhibitory properties towards α-amylase and DPP-IV enzymes than their intestinal digesta. Furthermore, the intestinal digesta of MS showed higher antioxidant and anti-inflammatory activities compared to the YS intestinal digesta. Overall, the results suggested that the gastrointestinal digestion of YS and MS displayed distinctive metabolic profiles together with varied bioactive potentials.
KW - Antioxidant
KW - Enzymes inhibitory potentials
KW - In vitro gastrointestinal digestion
KW - Metabolome profiling
KW - Phenolic content
KW - Soybean
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U2 - 10.1016/j.foodchem.2023.136050
DO - 10.1016/j.foodchem.2023.136050
M3 - Article
C2 - 37098305
AN - SCOPUS:85153036354
SN - 0308-8146
VL - 420
JO - Food Chemistry
JF - Food Chemistry
M1 - 136050
ER -