Metal-Based Nanomaterials for the Sensing of NSAIDS

Farah Quddus, Afzal Shah, Naimat Ullah, Iltaf Shah

Research output: Contribution to journalArticlepeer-review

Abstract

Cadmium sulfide and zinc oxide nanoparticles were prepared, characterized and used as electrode modifiers for the sensing of two non-steroidal anti-inflammatory drugs (NSAIDs): naproxen and mobic. The structural and morphological characterization of the synthesized nanoparticles was carried out by XRD, UV-Vis spectroscopy, FTIR and scanning electron microscopy. The electrode’s enhanced surface area facilitated the signal amplification of the selected NSAIDs. The CdS-modified glassy carbon electrode (GCE) enhanced the electro-oxidation signals of naproxen to four times that of the bare GCE, while the ZnO-modified GCE led to a two-fold enhancement in the electro-oxidation signals of mobic. The oxidation of both NSAIDs occurred in a pH-dependent manner, suggesting the involvement of protons in their electron transfer reactions. The experimental conditions for the sensing of naproxen and mobic were optimized and, under optimized conditions, the modified electrode surface demonstrated the qualities of sensitivity and selectivity, and a fast responsiveness to the target NSAIDs.

Original languageEnglish
Article number630
JournalNanomaterials
Volume14
Issue number7
DOIs
Publication statusPublished - Apr 2024

Keywords

  • cadmium sulfide
  • mobic
  • naproxen
  • NSAIDs
  • zinc oxide

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Materials Science

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