TY - JOUR
T1 - Methicillin resistant Staphylococcus aureus in the United Arab Emirates
T2 - a 12-year retrospective analysis of evolving trends
AU - The UAE AMR Surveillance Consortium
AU - Thomsen, Jens
AU - Abdulrazzaq, Najiba M.
AU - Menezes, Godfred Antony
AU - Moubareck, Carole Ayoub
AU - Everett, Dean B.
AU - Senok, Abiola
AU - Ahmed, Ahmed Elhag
AU - Yousef, Ahmed F.
AU - Alblooshi, Amna
AU - Alatoom, Adnan
AU - Hammadi, Ahmed Abdulkareem Al
AU - Enshasy, Alaa M.M.
AU - Madhi, Amal Mubarak
AU - Nabi, Anju
AU - Poddar, Anup Shashikant
AU - Jha, Arun Kumar
AU - Marzooqi, Ayesha Abdulla Al
AU - Aden, Bashir
AU - Jafri, Deeba
AU - Hong, Duckjin
AU - Al-Marzooq, Farah Ibrahim
AU - Dhaheri, Fatima Al
AU - Wahab, Ghada Abdel
AU - Khoder, Ghalia Abdul Khader
AU - Patil, Gitanjali Avishkar
AU - Ahmad, Hafiz
AU - Khalifa, Hazim
AU - Alzabi, Husein
AU - Alhashami, Ibrahim Alsayed Mustafa
AU - Akthar, Irfaan
AU - Stelling, John
AU - Diddi, Kavita
AU - Ramabhadran, Krishnaprasad
AU - Dabal, Laila Al
AU - Senghore, Madikay
AU - Ahmed, Manal Abdel Fattah
AU - Habous, Maya
AU - Zain, Moeena
AU - Maheshwari, Monika
AU - Alfaresi, Mubarak Saif
AU - Khan, Mushtaq
AU - Abdulrazzaq, Najiba
AU - Shirawi, Nehad Nabeel Al
AU - Helmy, Nesrin
AU - Nasa, Prashant
AU - Patil, Rajeshwari T.A.
AU - Kurahatti, Ratna A.
AU - Husain, Riyaz Amirali
AU - Sheek-Hussein, Mohamud M.
AU - Eltahir, Zahir Osman
N1 - Publisher Copyright:
© 2023 Thomsen, Abdulrazzaq, The UAE AMR Surveillance Consortium, Menezes, Ayoub Moubareck, Everett and Senok.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Introduction: Methicillin resistant Staphylococcus aureus (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains crucial. This study was carried out to assess MRSA trends in the United Arab Emirates (UAE) based on analysis of data from the national AMR surveillance program. Methods: We carried out a 12-year (2010–2021) retrospective analysis of MRSA demographic and microbiological data collected as part of the UAE national AMR surveillance program. Participating centers from across the country routinely submit AMR surveillance data collected by trained personnel to the National AMR Surveillance Committee, where data is analyzed using a unified WHONET platform. Data on non-duplicate isolates associated with clinical infections were obtained and included in the analysis. Results: A total of 29,414 non-duplicate MRSA isolates associated with clinical infections were reported between 2010 and 2021 (2010: n = 259; 2021: n = 4,996). MRSA represented 26.4% of all S. aureus (n = 111,623) isolates identified during the study period. In 2010, among the S. aureus isolates with reported oxacillin testing, 21.9% (n/N = 259/1,181) were identified as MRSA and this showed an increase to 33.5% (n/N = 4,996/14,925) in 2021. Although there was variation in the distribution of MRSA across the seven emirates of the country, most had an upward trend. Patient demographics reflected a male preponderance, with most being adults and from the outpatient setting. Isolates were mostly from skin and soft tissue infection specimens (72.5%; n/N = 21,335/29,414). Among the inpatients (N = 8,282), a total of 3,313 MRSA isolates were from specimens obtained ≤ 48 h after admission indicative of community acquired infection. Increasing resistance trends were observed for most antibiotics including ciprofloxacin, levofloxacin, moxifloxacin, erythromycin, gentamicin, trimethoprim-sulfamethoxazole, and quinupristin/dalfopristin. Low levels of resistance (0.0–0.8%) were sustained for linezolid except for 2015, 2016, and 2017 with 2.5, 2.6, and 2.9%, respectively. No confirmed vancomycin resistance was reported. Conclusion: The increasing trend of MRSA isolates associated with clinical infections in the hospital and community settings is a concern. Continued monitoring including incorporation of genomic surveillance and infection control measures are recommended to stem the dissemination.
AB - Introduction: Methicillin resistant Staphylococcus aureus (MRSA) is a major contributor to the global burden of antimicrobial resistance (AMR). As MRSA continues to evolve, the need for continued surveillance to evaluate trends remains crucial. This study was carried out to assess MRSA trends in the United Arab Emirates (UAE) based on analysis of data from the national AMR surveillance program. Methods: We carried out a 12-year (2010–2021) retrospective analysis of MRSA demographic and microbiological data collected as part of the UAE national AMR surveillance program. Participating centers from across the country routinely submit AMR surveillance data collected by trained personnel to the National AMR Surveillance Committee, where data is analyzed using a unified WHONET platform. Data on non-duplicate isolates associated with clinical infections were obtained and included in the analysis. Results: A total of 29,414 non-duplicate MRSA isolates associated with clinical infections were reported between 2010 and 2021 (2010: n = 259; 2021: n = 4,996). MRSA represented 26.4% of all S. aureus (n = 111,623) isolates identified during the study period. In 2010, among the S. aureus isolates with reported oxacillin testing, 21.9% (n/N = 259/1,181) were identified as MRSA and this showed an increase to 33.5% (n/N = 4,996/14,925) in 2021. Although there was variation in the distribution of MRSA across the seven emirates of the country, most had an upward trend. Patient demographics reflected a male preponderance, with most being adults and from the outpatient setting. Isolates were mostly from skin and soft tissue infection specimens (72.5%; n/N = 21,335/29,414). Among the inpatients (N = 8,282), a total of 3,313 MRSA isolates were from specimens obtained ≤ 48 h after admission indicative of community acquired infection. Increasing resistance trends were observed for most antibiotics including ciprofloxacin, levofloxacin, moxifloxacin, erythromycin, gentamicin, trimethoprim-sulfamethoxazole, and quinupristin/dalfopristin. Low levels of resistance (0.0–0.8%) were sustained for linezolid except for 2015, 2016, and 2017 with 2.5, 2.6, and 2.9%, respectively. No confirmed vancomycin resistance was reported. Conclusion: The increasing trend of MRSA isolates associated with clinical infections in the hospital and community settings is a concern. Continued monitoring including incorporation of genomic surveillance and infection control measures are recommended to stem the dissemination.
KW - antimicrobial resistance
KW - Arabian Gulf region
KW - methicillin resistant Staphylococcus aureus
KW - MRSA
KW - national surveillance
KW - United Arab Emirates
UR - http://www.scopus.com/inward/record.url?scp=85180482204&partnerID=8YFLogxK
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U2 - 10.3389/fpubh.2023.1244351
DO - 10.3389/fpubh.2023.1244351
M3 - Article
C2 - 38145065
AN - SCOPUS:85180482204
SN - 2296-2565
VL - 11
JO - Frontiers in Public Health
JF - Frontiers in Public Health
M1 - 1244351
ER -