Metoclopramide protection of cholinesterase from paraoxon inhibition

Georg A. Petroianu, Mohd Y. Hasan, Melita Kosanovic, C. Vijayasarathy, A. M. Saleh

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group I received 100 nM POX, Group 2 received 50 μM MCP. Group 3 received 100 nM POX + 50 μM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalVeterinary and Human Toxicology
Issue number5
Publication statusPublished - Oct 2003

ASJC Scopus subject areas

  • Toxicology
  • General Veterinary
  • Health, Toxicology and Mutagenesis


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