Metoclopramide protection of cholinesterase from paraoxon inhibition

Georg A. Petroianu; Mohd Y. Hasan; Melita Kosanovic; C. Vijayasarathy; A. M. Saleh

Metoclopramide protection of cholinesterase from paraoxon inhibition

Georg A. Petroianu, Mohd Y. Hasan, Melita Kosanovic, C. Vijayasarathy, A. M. Saleh

Department of Pharmacology and Therapeutics

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group I received 100 nM POX, Group 2 received 50 μM MCP. Group 3 received 100 nM POX + 50 μM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.

Original language	English
Pages (from-to)	251-253
Number of pages	3
Journal	Veterinary and Human Toxicology
Volume	45
Issue number	5
Publication status	Published - Oct 2003

ASJC Scopus subject areas

Toxicology
General Veterinary
Health, Toxicology and Mutagenesis

Cite this

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title = "Metoclopramide protection of cholinesterase from paraoxon inhibition",

abstract = "This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group I received 100 nM POX, Group 2 received 50 μM MCP. Group 3 received 100 nM POX + 50 μM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.",

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T1 - Metoclopramide protection of cholinesterase from paraoxon inhibition

AU - Petroianu, Georg A.

AU - Hasan, Mohd Y.

AU - Kosanovic, Melita

AU - Vijayasarathy, C.

AU - Saleh, A. M.

PY - 2003/10

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N2 - This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group I received 100 nM POX, Group 2 received 50 μM MCP. Group 3 received 100 nM POX + 50 μM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.

AB - This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group I received 100 nM POX, Group 2 received 50 μM MCP. Group 3 received 100 nM POX + 50 μM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.

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JF - Veterinary and Human Toxicology

IS - 5

ER -

Metoclopramide protection of cholinesterase from paraoxon inhibition

Abstract

ASJC Scopus subject areas

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