Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents

Abdelouahid Samadi; Daniel Silva; Mourad Chioua; Maria Do Carmo Carreiras; José Marco-Contelles

doi:10.1080/00397911.2010.515360

Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents

Abdelouahid Samadi
, Daniel Silva
, Mourad Chioua
, Maria Do Carmo Carreiras
, José Marco-Contelles

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts.

Original language	English
Pages (from-to)	2859-2869
Number of pages	11
Journal	Synthetic Communications
Volume	41
Issue number	19
DOIs	https://doi.org/10.1080/00397911.2010.515360
Publication status	Published - 2011
Externally published	Yes

Keywords

2-(N, N-dimethyl)-aminopyridines
2-aminopyridines
2-chloropyridines
Amides
Amination
Microwave irradiation

ASJC Scopus subject areas

Organic Chemistry

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10.1080/00397911.2010.515360

Cite this

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title = "Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents",

abstract = "A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts.",

keywords = "2-(N, N-dimethyl)-aminopyridines, 2-aminopyridines, 2-chloropyridines, Amides, Amination, Microwave irradiation",

author = "Abdelouahid Samadi and Daniel Silva and Mourad Chioua and Carreiras, \{Maria Do Carmo\} and Jos{\'e} Marco-Contelles",

note = "Funding Information: The present work has been supported by MEC Grant SAF2006-08764-C02-01, Comunidad de Madrid (S/SAL-0275-2006), Instituto de Salud Carlos III [RETIC RENEVAS (RD06/0026/1002)], and AECI (A/07492/07). A. S. thanks CSCI for the JAE-doc contract. M. C. thanks the Instituto de Salud Carlos III (Ministerio de Salud y Consumo) for a postdoctoral fellowship.",

year = "2011",

doi = "10.1080/00397911.2010.515360",

language = "English",

volume = "41",

pages = "2859--2869",

journal = "Synthetic Communications",

issn = "0039-7911",

publisher = "Taylor and Francis Ltd.",

number = "19",

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TY - JOUR

T1 - Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents

AU - Samadi, Abdelouahid

AU - Silva, Daniel

AU - Chioua, Mourad

AU - Carreiras, Maria Do Carmo

AU - Marco-Contelles, José

N1 - Funding Information: The present work has been supported by MEC Grant SAF2006-08764-C02-01, Comunidad de Madrid (S/SAL-0275-2006), Instituto de Salud Carlos III [RETIC RENEVAS (RD06/0026/1002)], and AECI (A/07492/07). A. S. thanks CSCI for the JAE-doc contract. M. C. thanks the Instituto de Salud Carlos III (Ministerio de Salud y Consumo) for a postdoctoral fellowship.

PY - 2011

Y1 - 2011

N2 - A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts.

AB - A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts.

KW - 2-(N, N-dimethyl)-aminopyridines

KW - 2-aminopyridines

KW - 2-chloropyridines

KW - Amides

KW - Amination

KW - Microwave irradiation

UR - https://www.scopus.com/pages/publications/79960014572

UR - https://www.scopus.com/pages/publications/79960014572#tab=citedBy

U2 - 10.1080/00397911.2010.515360

DO - 10.1080/00397911.2010.515360

M3 - Article

AN - SCOPUS:79960014572

SN - 0039-7911

VL - 41

SP - 2859

EP - 2869

JO - Synthetic Communications

JF - Synthetic Communications

IS - 19

ER -

Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents

Abstract

Keywords

ASJC Scopus subject areas

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