Missing-Values Imputation Algorithms for Microarray Gene Expression Data

Kohbalan Moorthy, Aws Naser Jaber, Mohd Arfian Ismail, Ferda Ernawan, Mohd Saberi Mohamad, Safaai Deris

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)


In gene expression studies, missing values are a common problem with important consequences for the interpretation of the final data (Satija et al., Nat Biotechnol 33(5):495, 2015). Numerous bioinformatics examination tools are used for cancer prediction, including the data set matrix (Bailey et al., Cell 173(2):371–385, 2018); thus, it is necessary to resolve the problem of missing-values imputation. This chapter presents a review of the research on missing-values imputation approaches for gene expression data. By using local and global correlation of the data, we were able to focus mostly on the differences between the algorithms. We classified the algorithms as global, hybrid, local, or knowledge-based techniques. Additionally, this chapter presents suitable assessments of the different approaches. The purpose of this review is to focus on developments in the current techniques for scientists rather than applying different or newly developed algorithms with identical functional goals. The aim was to adapt the algorithms to the characteristics of the data.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages12
Publication statusPublished - 2019
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Cancer Informatics
  • Computational intelligence
  • Gene expression data
  • Microarray
  • Missing-values imputation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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