Modeling Drying Behavior of an Aqueous Chitosan Single Droplet Using the Reaction Engineering Approach

Belal Al Zaitone, Abdulrahim Al-Zahrani

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Spray drying of Chitosan solutions to prepare microparticles either using pilot or industrial scale spray dryer is a complex process; tracking morphological changes and obtaining drying kinetics of a single droplet would be very difficult. The acoustic levitator being a non-intrusive method is a useful experimental apparatus that enables particle/droplet suspension in the gaseous medium and capable of mimicking the drying process in a spray dryer. The drying of chitosan aqueous solutions into solid particles was investigated. The prediction of the size and drying kinetics until the formation of the solid structure was performed in an acoustic levitator. Studying the drying of single droplets is crucial for revealing the influence of the drying process parameters on the formation of dried particles. Droplets with initial chitosan concentration (10, 20, and 30 mg/ml) were investigated at different air-drying temperatures. A Reaction Engineering Approach (REA) model was developed and compared with the experimental drying curves, a very well agreement was found between the drying experiments and the REA model with a relative error of about 3% between the initial droplet mass and predicted droplet mass by the REA model.

Original languageEnglish
Article number315
JournalAAPS PharmSciTech
Issue number8
Publication statusPublished - Nov 2020
Externally publishedYes


  • acoustic levitation
  • chitosan
  • microspheres
  • REA model
  • single droplet drying

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'Modeling Drying Behavior of an Aqueous Chitosan Single Droplet Using the Reaction Engineering Approach'. Together they form a unique fingerprint.

Cite this