MOF nanoparticles coated by lipid bilayers and their uptake by cancer cells

Stefan Wuttke; Simone Braig; Tobias Preiß; Andreas Zimpel; Johannes Sicklinger; Claudia Bellomo; Joachim O. Rädler; Angelika M. Vollmar; Thomas Bein

doi:10.1039/c5cc06767g

MOF nanoparticles coated by lipid bilayers and their uptake by cancer cells

Stefan Wuttke
, Simone Braig
, Tobias Preiß
, Andreas Zimpel
, Johannes Sicklinger
, Claudia Bellomo
, Joachim O. Rädler
, Angelika M. Vollmar
, Thomas Bein

Research output: Contribution to journal › Article › peer-review

203 Citations (Scopus)

Abstract

We report the synthesis of MOF@lipid nanoparticles as a versatile and powerful novel class of nanocarriers based on metal-organic frameworks (MOFs). We show that the MOF@lipid system can effectively store dye molecules inside the porous scaffold of the MOF while the lipid bilayer prevents their premature release. Efficient uptake of the MOF@lipid nanoparticles by cancer cells makes these nanocarriers promising for drug delivery and diagnostic purposes.

Original language	English
Pages (from-to)	15752-15755
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	87
DOIs	https://doi.org/10.1039/c5cc06767g
Publication status	Published - 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc06767g

Cite this

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abstract = "We report the synthesis of MOF@lipid nanoparticles as a versatile and powerful novel class of nanocarriers based on metal-organic frameworks (MOFs). We show that the MOF@lipid system can effectively store dye molecules inside the porous scaffold of the MOF while the lipid bilayer prevents their premature release. Efficient uptake of the MOF@lipid nanoparticles by cancer cells makes these nanocarriers promising for drug delivery and diagnostic purposes.",

author = "Stefan Wuttke and Simone Braig and Tobias Prei{\ss} and Andreas Zimpel and Johannes Sicklinger and Claudia Bellomo and R{\"a}dler, \{Joachim O.\} and Vollmar, \{Angelika M.\} and Thomas Bein",

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language = "English",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - MOF nanoparticles coated by lipid bilayers and their uptake by cancer cells

AU - Wuttke, Stefan

AU - Braig, Simone

AU - Preiß, Tobias

AU - Zimpel, Andreas

AU - Sicklinger, Johannes

AU - Bellomo, Claudia

AU - Rädler, Joachim O.

AU - Vollmar, Angelika M.

AU - Bein, Thomas

PY - 2015

Y1 - 2015

N2 - We report the synthesis of MOF@lipid nanoparticles as a versatile and powerful novel class of nanocarriers based on metal-organic frameworks (MOFs). We show that the MOF@lipid system can effectively store dye molecules inside the porous scaffold of the MOF while the lipid bilayer prevents their premature release. Efficient uptake of the MOF@lipid nanoparticles by cancer cells makes these nanocarriers promising for drug delivery and diagnostic purposes.

AB - We report the synthesis of MOF@lipid nanoparticles as a versatile and powerful novel class of nanocarriers based on metal-organic frameworks (MOFs). We show that the MOF@lipid system can effectively store dye molecules inside the porous scaffold of the MOF while the lipid bilayer prevents their premature release. Efficient uptake of the MOF@lipid nanoparticles by cancer cells makes these nanocarriers promising for drug delivery and diagnostic purposes.

UR - https://www.scopus.com/pages/publications/84946053826

UR - https://www.scopus.com/pages/publications/84946053826#tab=citedBy

U2 - 10.1039/c5cc06767g

DO - 10.1039/c5cc06767g

M3 - Article

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AN - SCOPUS:84946053826

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VL - 51

SP - 15752

EP - 15755

JO - Chemical Communications

JF - Chemical Communications

IS - 87

ER -

MOF nanoparticles coated by lipid bilayers and their uptake by cancer cells

Abstract

UN SDGs

ASJC Scopus subject areas

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