Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

Syed Sherazi, Asim Abbasi, Abdullah Jamil, Mohammad Uzair, Ayesha Ikram, Shanzay Qamar, Adediji Olamide, Muhammad Arshad, Peter Fried, Milos Ljubisavljevic, Ran Wang, Shahid Bashir

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer's disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes (e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA- and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging.

Original languageEnglish
Pages (from-to)959-968
Number of pages10
JournalNeural Regeneration Research
Volume18
Issue number5
DOIs
Publication statusPublished - May 2023

Keywords

  • Alzheimer's disease
  • DNA sequence
  • aging
  • epigenetics
  • immune
  • non-coding RNA
  • oligonucleotides
  • telomere-associated

ASJC Scopus subject areas

  • Developmental Neuroscience

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