Monitoring the metabolism of moexipril to moexiprilat using high-performance liquid chromatography-electrospray ionization mass spectrometry

J. Kóti; V. Háda; G. Petroianu; M. Y. Hasan; K. Tekes; Z. Szücs; H. Kalász

doi:10.1093/chromsci/44.4.214

Monitoring the metabolism of moexipril to moexiprilat using high-performance liquid chromatography-electrospray ionization mass spectrometry

J. Kóti
, V. Háda
, G. Petroianu
, M. Y. Hasan
, K. Tekes
, Z. Szücs
, H. Kalász

Department of Pharmacology and Therapeutics

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

High-performance liquid chromatography combined with a UV absorbance detector and electrospray ionization mass spectrometer is used for the simultaneous analysis of moexipril and moexiprilat in biological samples. Moexipril and moexiprilat are determined in samples metabolized by rat and human liver microsomal preparations, and also in rat urine. The calibration curve is linear in the ng/mL and μg/mL concentration range of the injected moexipril.

Original language	English
Pages (from-to)	214-218
Number of pages	5
Journal	Journal of chromatographic science
Volume	44
Issue number	4
DOIs	https://doi.org/10.1093/chromsci/44.4.214
Publication status	Published - Apr 2006

ASJC Scopus subject areas

Analytical Chemistry

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10.1093/chromsci/44.4.214

Cite this

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title = "Monitoring the metabolism of moexipril to moexiprilat using high-performance liquid chromatography-electrospray ionization mass spectrometry",

abstract = "High-performance liquid chromatography combined with a UV absorbance detector and electrospray ionization mass spectrometer is used for the simultaneous analysis of moexipril and moexiprilat in biological samples. Moexipril and moexiprilat are determined in samples metabolized by rat and human liver microsomal preparations, and also in rat urine. The calibration curve is linear in the ng/mL and μg/mL concentration range of the injected moexipril.",

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note = "Funding Information: This project was sponsored by the Hungarian National Science and Research Fund (Budapest, Hungary) (OTKA T049492) and the Ministry of Health Social and Family Social Affairs of Hungary, Budapest (ETT 133/2003). This work was also supported by an intramural grant (\# NP/04/12) from the Faculty of Medicine \& Health Sciences (FMHS) United Arab Emirates University.",

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doi = "10.1093/chromsci/44.4.214",

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AU - Kóti, J.

AU - Háda, V.

AU - Petroianu, G.

AU - Hasan, M. Y.

AU - Tekes, K.

AU - Szücs, Z.

AU - Kalász, H.

N1 - Funding Information: This project was sponsored by the Hungarian National Science and Research Fund (Budapest, Hungary) (OTKA T049492) and the Ministry of Health Social and Family Social Affairs of Hungary, Budapest (ETT 133/2003). This work was also supported by an intramural grant (# NP/04/12) from the Faculty of Medicine & Health Sciences (FMHS) United Arab Emirates University.

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N2 - High-performance liquid chromatography combined with a UV absorbance detector and electrospray ionization mass spectrometer is used for the simultaneous analysis of moexipril and moexiprilat in biological samples. Moexipril and moexiprilat are determined in samples metabolized by rat and human liver microsomal preparations, and also in rat urine. The calibration curve is linear in the ng/mL and μg/mL concentration range of the injected moexipril.

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Monitoring the metabolism of moexipril to moexiprilat using high-performance liquid chromatography-electrospray ionization mass spectrometry

Abstract

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