Monoamines and cortisol as potential mediators of the relationship between exercise and depressive symptoms

Lara S.F. Carneiro, Maria Paula Mota, Maria Augusta Vieira-Coelho, Rita C. Alves, António Manuel Fonseca, José Vasconcelos-Raposo

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A randomized controlled trial was conducted to assess the effects of exercise plus pharmacotherapy on monoamine neurotransmitters (dopamine, noradrenaline, adrenaline, serotonin) and cortisol levels. A total of 26 women with clinical depression were randomly assigned to one of the two groups: aerobic exercise plus pharmacotherapy or only pharmacotherapy. The exercise program consisted of aerobic exercise, 45–50 min/session, three times/week, for 16 weeks. The biological parameters were measured before and after the exercise program. Adding exercise to pharmacotherapy had no additional effects on monoamines and cortisol plasma levels. These data are preliminary outcomes from a small sample and should be replicated.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume267
Issue number2
DOIs
Publication statusPublished - Mar 1 2017
Externally publishedYes

Keywords

  • Aerobic exercise
  • Catecholamines
  • Cortisol
  • Depression
  • Women

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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