TY - JOUR
T1 - Mother-child class I HLA concordance increases perinatal human immunodeficiency virus type 1 transmission
AU - MacDonald, Kelly S.
AU - Embree, Joanne
AU - Njenga, Simon
AU - Nagelkerke, Nico J.D.
AU - Ngatia, Irene
AU - Mohammed, Zeena
AU - Barber, Brian H.
AU - Ndinya-Achola, Jeckoniah
AU - Bwayo, Job
AU - Plummer, Francis A.
N1 - Funding Information:
Financial support: National Research Development Program (Canada), International Development Research Centre (Canada), and Medical Research Council of Canada. K.S.M. was a recipient of a fellowship from the Medical Research Council of Canada, and F.A.P. is a Senior Scientist of the Medical Research Council of Canada.
PY - 1998
Y1 - 1998
N2 - Major histocompatibility complex (MHC) gene products are expressed on human immunodeficiency virus (HIV)-infected cells and incorporated into the lipid envelope of HIV virions. Macaques immunized with human MHC gene products are protected from simian immunodeficiency virus challenge when the virus is grown in cells expressing the same MHC alleles. To relate these findings to mother-to-child transmission of HIV-1, investigations of whether sharing HLA between mother and infant influenced the risk of transmission of HIV-1 to the child were carried out. Class I HLA concordance was independently associated with a stepwise increase in the risk of perinatal HIV-1 transmission for each additional concordant allele (odds ratio, 2.63; 95% confidence interval, 1.36-5.07; P = .003). Thus, discordant HLA may provide infants with a means of protection against HIV-1 as a result of allogeneic infant anti-maternal MHC immune responses.
AB - Major histocompatibility complex (MHC) gene products are expressed on human immunodeficiency virus (HIV)-infected cells and incorporated into the lipid envelope of HIV virions. Macaques immunized with human MHC gene products are protected from simian immunodeficiency virus challenge when the virus is grown in cells expressing the same MHC alleles. To relate these findings to mother-to-child transmission of HIV-1, investigations of whether sharing HLA between mother and infant influenced the risk of transmission of HIV-1 to the child were carried out. Class I HLA concordance was independently associated with a stepwise increase in the risk of perinatal HIV-1 transmission for each additional concordant allele (odds ratio, 2.63; 95% confidence interval, 1.36-5.07; P = .003). Thus, discordant HLA may provide infants with a means of protection against HIV-1 as a result of allogeneic infant anti-maternal MHC immune responses.
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U2 - 10.1086/514243
DO - 10.1086/514243
M3 - Article
C2 - 9498431
AN - SCOPUS:17344369061
SN - 0022-1899
VL - 177
SP - 551
EP - 556
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -