TY - JOUR
T1 - Motor and behavioral effects of moringa oleifera leaf extract
AU - Al-Abri, Mohammed
AU - Ashique, Mohammed
AU - Ramkumar, Aishwarya
AU - Nemmar, Abderrahim
AU - Ali, Badreldin H.
N1 - Funding Information:
Financial support was from the College of Medicine and Health Sciences, Sultan Qaboos University. We thank Dr Ibrahim Musa for providing the M. oleifera plant samples.
Publisher Copyright:
© 2018 Natural Product Incorporation. All Rights Reserved.
PY - 2018/1
Y1 - 2018/1
N2 - Moringa oleifera is a medicinal plant widely used in many parts of the world for hypertension, pain and epilepsy. The aim of this study was to determine the effect of M. oleifera aqueous leaf extract on motor and behavioral activities of healthy mice. Male mice were randomly divided into a control group (given 0.9% NaCl orally) and three groups treated with the extract at doses of 100, 200, and 400 mg/kg/day for 14 consecutive days. Motor and behavioral activity were evaluated by quantifying motor activity, exploration (hole-board), neuro-muscular coordination (rota rod treadmill), pain (hot plate, cold-water tail flick, and acetic acid-induced abdominal constriction), and depression (forced swimming test, FST). Administration of M. oleifera extract had a significant and dose-dependent antinociceptive action in both thermal and chemical tests (p < 0.05). The extract (400 mg/kg) caused a reduction in exploration activity and neuromuscular coordination, and decreased the mobility time in the FST, suggesting an antidepressant-like action. Motor activity was not significantly affected by any of the doses used. The results suggest that the plant aqueous extract may have a dose-dependent central nervous system (CNS) depressant action.
AB - Moringa oleifera is a medicinal plant widely used in many parts of the world for hypertension, pain and epilepsy. The aim of this study was to determine the effect of M. oleifera aqueous leaf extract on motor and behavioral activities of healthy mice. Male mice were randomly divided into a control group (given 0.9% NaCl orally) and three groups treated with the extract at doses of 100, 200, and 400 mg/kg/day for 14 consecutive days. Motor and behavioral activity were evaluated by quantifying motor activity, exploration (hole-board), neuro-muscular coordination (rota rod treadmill), pain (hot plate, cold-water tail flick, and acetic acid-induced abdominal constriction), and depression (forced swimming test, FST). Administration of M. oleifera extract had a significant and dose-dependent antinociceptive action in both thermal and chemical tests (p < 0.05). The extract (400 mg/kg) caused a reduction in exploration activity and neuromuscular coordination, and decreased the mobility time in the FST, suggesting an antidepressant-like action. Motor activity was not significantly affected by any of the doses used. The results suggest that the plant aqueous extract may have a dose-dependent central nervous system (CNS) depressant action.
KW - Analgesia
KW - Behavior
KW - Depressant-like action
KW - Mice
KW - Moringa oleifera
KW - Moringaceae
KW - Motor activity
UR - http://www.scopus.com/inward/record.url?scp=85048480952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048480952&partnerID=8YFLogxK
U2 - 10.1177/1934578x1801300126
DO - 10.1177/1934578x1801300126
M3 - Article
AN - SCOPUS:85048480952
SN - 1934-578X
VL - 13
SP - 89
EP - 92
JO - Natural Product Communications
JF - Natural Product Communications
IS - 1
ER -