MUC1 (CD227): A multi-tasked molecule

Vasso Apostolopoulos; Lily Stojanovska; Sharron E. Gargosky

doi:10.1007/s00018-015-2014-z

MUC1 (CD227): A multi-tasked molecule

Vasso Apostolopoulos, Lily Stojanovska, Sharron E. Gargosky

Research output: Contribution to journal › Review article › peer-review

77 Citations (Scopus)

Abstract

Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.

Original language	English
Pages (from-to)	4475-4500
Number of pages	26
Journal	Cellular and Molecular Life Sciences
Volume	72
Issue number	23
DOIs	https://doi.org/10.1007/s00018-015-2014-z
Publication status	Published - Aug 21 2015
Externally published	Yes

Keywords

CD227
EMA
MUC1
MUC1 and cancer
MUC1 and disease
MUC1 expression
MUC1 isoforms
MUC1 pathogens
MUC1 structure
PEM

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s00018-015-2014-z

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title = "MUC1 (CD227): A multi-tasked molecule",

abstract = "Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.",

keywords = "CD227, EMA, MUC1, MUC1 and cancer, MUC1 and disease, MUC1 expression, MUC1 isoforms, MUC1 pathogens, MUC1 structure, PEM",

author = "Vasso Apostolopoulos and Lily Stojanovska and Gargosky, {Sharron E.}",

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year = "2015",

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doi = "10.1007/s00018-015-2014-z",

language = "English",

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TY - JOUR

T1 - MUC1 (CD227)

T2 - A multi-tasked molecule

AU - Apostolopoulos, Vasso

AU - Stojanovska, Lily

AU - Gargosky, Sharron E.

PY - 2015/8/21

Y1 - 2015/8/21

N2 - Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.

AB - Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.

KW - CD227

KW - EMA

KW - MUC1

KW - MUC1 and cancer

KW - MUC1 and disease

KW - MUC1 expression

KW - MUC1 isoforms

KW - MUC1 pathogens

KW - MUC1 structure

KW - PEM

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U2 - 10.1007/s00018-015-2014-z

DO - 10.1007/s00018-015-2014-z

M3 - Review article

C2 - 26294353

AN - SCOPUS:84946472871

SN - 1420-682X

VL - 72

SP - 4475

EP - 4500

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 23

ER -

MUC1 (CD227): A multi-tasked molecule

Abstract

Keywords

ASJC Scopus subject areas

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