Multi-objective optimization using genetic algorithm for gene selection from microarray data

Mohd Saberi Mohamad, Sigeru Omatu, Safaai Deris, Michifumi Yoshioka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Microarray technology has been increasingly used in cancer research because of its potential for measuring expression levels of thousands of genes simultaneously in tissue samples. It is used to collect the information from tissue samples regarding gene expression differences that could be useful for cancer classification. However, this classification task faces many challenges due to availability of a smaller number of samples compared to the huge number of genes, and many of the genes are not relevant to the classification. It has been shown that selecting a small subset of genes can lead to an improved accuracy of the classification. Hence, this paper proposes a solution to the problem of gene selection by using a multi-objective approach in genetic algorithm. This approach is experimented on two microarray data sets such as Lung cancer and Mixed-Lineage Leukemia cancer. It obtains encouraging result on those data sets as compared with an approach that uses singleobjective approach.

Original languageEnglish
Title of host publicationProceedings of the International Conference on Computer and Communication Engineering 2008, ICCCE08
Subtitle of host publicationGlobal Links for Human Development
Pages1331-1334
Number of pages4
DOIs
Publication statusPublished - 2008
Externally publishedYes
EventInternational Conference on Computer and Communication Engineering 2008, ICCCE08: Global Links for Human Development - Kuala Lumpur, Malaysia
Duration: May 13 2008May 15 2008

Publication series

NameProceedings of the International Conference on Computer and Communication Engineering 2008, ICCCE08: Global Links for Human Development

Other

OtherInternational Conference on Computer and Communication Engineering 2008, ICCCE08: Global Links for Human Development
Country/TerritoryMalaysia
CityKuala Lumpur
Period5/13/085/15/08

ASJC Scopus subject areas

  • Computer Science Applications
  • Human-Computer Interaction

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