Multiphoton excitation of Rose Bengal to induce capillary photo-thrombosis

P. Delafontaine-Martel, Xuecong Lu, Cong Zhang, Rafat Damseh, Frédéric Lesage, Paul J. Marchand

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In this work, we demonstrate the application of Rose Bengal as a photo-thrombotic agent using 2-photon and 3-photon excitation by measuring the response to multiphotonic excitation. We also demonstrate, in the case of 2-photon excitation, that the mechanism used is different from laser injury alone with a control group of FitC injected mice. Preliminary results show that a capillary photo-thrombosis could be performed up to 200 m and OCT imaging could confirm blockage.

Original languageEnglish
Title of host publicationOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
EditorsV. X. D. Yang, Q. M. Luo, S. K. Mohanty, J. Ding, A. W. Roe, J. M. Kainerstorfer, L. Fu, S. Shoham
PublisherSPIE
ISBN (Electronic)9781510640931
DOIs
Publication statusPublished - 2021
Externally publishedYes
EventOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics 2021 - Virtual, Online, United States
Duration: Mar 6 2021Mar 11 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11629
ISSN (Print)1605-7422

Conference

ConferenceOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics 2021
Country/TerritoryUnited States
CityVirtual, Online
Period3/6/213/11/21

Keywords

  • Multiphotonic
  • Photothrombosis
  • Photothrombotic model
  • Rose Bengal
  • Vascular dynamics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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