Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility

Oxytocin is a small peptide hormone with multiple sites of action in human body. It regulates a large number of reproduction-related processes in all species. Particularly important is its ability to stimulate uterine contractility. This is achieved by multiple mechanisms involving sarcoplasmic reticulum CaCa²⁺ release and sensitization of the contractile apparatus to Ca²⁺. In this paper, we review the data published by us and other groups on oxytocin-induced modulation of uterine contractility. We conclude that sensitization of contractile apparatus to CaCa²⁺ is the most relevant physiological effect of oxytocin on human myometrium.