Muscarinic M3 receptor subtype gene expression in the human heart

I. Hellgren, A. Mustafa, M. Riazi, I. Suliman, C. Sylvén, A. Adem

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

The heart is an important target organ for cholinergic function. In this study, muscarinic receptor subtype(s) in the human heart were determined using reverse transcription-polymerase chain reaction. Our results demonstrated muscarinic receptor M2 and M3 subtype RNA in left/right atria/ventricles of donor hearts. Receptor autoradiography analysis using selective muscarinic ligands indicated an absence of M1 receptor subtype in the human heart. The level of muscarinic receptor binding in atria was two to three times greater than in ventricles. Our results suggest that muscarinic receptors in the human heart are of the M2 and M3 subtypes. This is the first report of M3 receptors in the human myocardium.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalCellular and Molecular Life Sciences
Volume57
Issue number1
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Atrium
  • Heart failure
  • Human
  • Muscarinic receptor
  • Protein
  • Subtypes
  • Ventricle
  • mRNA

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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