TY - JOUR
T1 - Mycobacterium tuberculosis in the United Arab Emirates
T2 - Evidence of local transmission with unique strains
AU - Dissanayake, S.
AU - Usmani, A.
AU - Sheikh, F. A.
AU - Sheek-Hussein, M.
AU - Ameen, A. M.
AU - Lukic, M. L.
N1 - Funding Information:
Acknowledgements This work was supportedi n part by a grantf rom the Sheikh Hamdan Awards for Medical Researcha nd by the Faculty of Medicine and Health Sciences,U .A.E., to S. D. We thank the Director, Al Ain Hospital, for permissiont o carry out this work and Dr D. Van Soolingen and his staff at the M. tuberculosis Reference Laboratory, Bilthoven, The Netherlands,f or RBLP analysis.
PY - 2001
Y1 - 2001
N2 - A retrospective epidemiological analysis was performed of Mycobacterium tuberculosis infections in the Al Ain Medical District, Al Ain, United Arab Emirates (U.A.E.) during the period 1995-2000. The mean incidence for the study period was 7.1%, more than 3 times that reported for the period 1983-1992 (2.1%). For the years 1997 through 2000, the highest incidences (∼5-7% of tested) were from health care facilities that cater exclusively for citizens and long-term residents of the U.A.E. Corresponding rates for the immigrant visa applicants (non-citizens) were lower and showed a dramatic decrease from ∼18% in 1995 to ∼2% in 2000. Most importantly, the number of multidrug-resistant cases showed an increase from 1.4% during the period August 1997-December 1998 to 8.5% during the period January 1999-July 2000. Analysis of 7 different isolates by restriction fragment length polymorphism (RFLP) showed RFLP patterns that did not match >4000 individual patterns from 32 countries, suggesting the possible presence of M. tuberculosis strains unique to the U.A.E. Our data demonstrate local transmission of M. tuberculosis in the Al Ain Medical Region of the U.A.E.
AB - A retrospective epidemiological analysis was performed of Mycobacterium tuberculosis infections in the Al Ain Medical District, Al Ain, United Arab Emirates (U.A.E.) during the period 1995-2000. The mean incidence for the study period was 7.1%, more than 3 times that reported for the period 1983-1992 (2.1%). For the years 1997 through 2000, the highest incidences (∼5-7% of tested) were from health care facilities that cater exclusively for citizens and long-term residents of the U.A.E. Corresponding rates for the immigrant visa applicants (non-citizens) were lower and showed a dramatic decrease from ∼18% in 1995 to ∼2% in 2000. Most importantly, the number of multidrug-resistant cases showed an increase from 1.4% during the period August 1997-December 1998 to 8.5% during the period January 1999-July 2000. Analysis of 7 different isolates by restriction fragment length polymorphism (RFLP) showed RFLP patterns that did not match >4000 individual patterns from 32 countries, suggesting the possible presence of M. tuberculosis strains unique to the U.A.E. Our data demonstrate local transmission of M. tuberculosis in the Al Ain Medical Region of the U.A.E.
KW - Drug resistance
KW - Incidence
KW - Mycobacterium tuberculosis
KW - RFLP patterns
KW - Trends
KW - United Arab Emirates
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U2 - 10.1016/S0035-9203(01)90088-4
DO - 10.1016/S0035-9203(01)90088-4
M3 - Article
C2 - 11816427
AN - SCOPUS:0035724892
SN - 0035-9203
VL - 95
SP - 591
EP - 594
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 6
ER -