Abstract
The present study envisages evaluation of the cardioprotective efficacy of Ocimum sanctum (Os) (Tulsi) in the experimental model of isoproterenol (ISP)-induced myocardial necrosis. Wistar male albino mature rats were randomly divided into four main groups: sham, ISP-control, Os control and Os-treated. Os-control and Os-treated groups were further divided into three subgroups and administered with 25, 75 and 150 mg/kg Os orally, once daily for a month. On the 29th and 30th day, animals of the ISP-control and Os-treated groups received ISP (85 mg/kg) subcutaneously at an interval of 24 h. On the 31st day, 24 h after the second dose of ISP, the haemodynamic variables were recorded and the animals were sacrificed for biochemical and histopathological studies. Significant ventricular dysfunction, myocardial necrosis and depletion of endogenous antioxidants were observed in the ISP-control group compared to sham. Os pre-treatment augmented the basal endogenous antioxidants and restored the antioxidant status of the heart. The myocardial salvaging beneficial effects also translated into functional recovery of the myocardium. Histopathological studies further confirm its myocardial salvaging effects. Our study emphasizes the cardioprotective effect of Os against ISP-induced myocardial necrosis. The present study has demonstrated the cardioprotective effects of Os, which likely result from improved ventricular function, augmentation of endogenous antioxidants and suppression of oxidative stress.
| Original language | English |
|---|---|
| Pages (from-to) | 667-672 |
| Number of pages | 6 |
| Journal | Current Science |
| Volume | 91 |
| Issue number | 5 |
| Publication status | Published - Sept 10 2006 |
| Externally published | Yes |
Keywords
- Antioxidants
- Isoproterenol
- Medicinal herbs
- Myocardial infarction
- Ocimum sanctum
ASJC Scopus subject areas
- General