N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

Oscar M. Bautista-Aguilera; Abdelouahid Samadi; Mourad Chioua; Katarina Nikolic; Slavica Filipic; Danica Agbaba; Elena Soriano; Lucía De Andrés; María Isabel Rodríguez-Franco; Stefano Alcaro; Rona R. Ramsay; Francesco Ortuso; Matilde Yañez; José Marco-Contelles

doi:10.1021/jm501501a

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

Oscar M. Bautista-Aguilera
, Abdelouahid Samadi
, Mourad Chioua
, Katarina Nikolic
, Slavica Filipic
, Danica Agbaba
, Elena Soriano
, Lucía De Andrés
, María Isabel Rodríguez-Franco
, Stefano Alcaro
, Rona R. Ramsay
, Francesco Ortuso
, Matilde Yañez
, José Marco-Contelles

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.

Original language	English
Pages (from-to)	10455-10463
Number of pages	9
Journal	Journal of Medicinal Chemistry
Volume	57
Issue number	24
DOIs	https://doi.org/10.1021/jm501501a
Publication status	Published - Dec 26 2014
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm501501a

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Bautista-Aguilera, O. M., Samadi, A., Chioua, M., Nikolic, K., Filipic, S., Agbaba, D., Soriano, E., De Andrés, L., Rodríguez-Franco, M. I., Alcaro, S., Ramsay, R. R., Ortuso, F., Yañez, M., & Marco-Contelles, J. (2014). N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. Journal of Medicinal Chemistry, 57(24), 10455-10463. https://doi.org/10.1021/jm501501a

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. / Bautista-Aguilera, Oscar M.; Samadi, Abdelouahid; Chioua, Mourad et al.
In: Journal of Medicinal Chemistry, Vol. 57, No. 24, 26.12.2014, p. 10455-10463.

Research output: Contribution to journal › Article › peer-review

Bautista-Aguilera, OM, Samadi, A, Chioua, M, Nikolic, K, Filipic, S, Agbaba, D, Soriano, E, De Andrés, L, Rodríguez-Franco, MI, Alcaro, S, Ramsay, RR, Ortuso, F, Yañez, M & Marco-Contelles, J 2014, 'N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor', Journal of Medicinal Chemistry, vol. 57, no. 24, pp. 10455-10463. https://doi.org/10.1021/jm501501a

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title = "N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor",

abstract = "On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.",

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AU - Samadi, Abdelouahid

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AU - Agbaba, Danica

AU - Soriano, Elena

AU - De Andrés, Lucía

AU - Rodríguez-Franco, María Isabel

AU - Alcaro, Stefano

AU - Ramsay, Rona R.

AU - Ortuso, Francesco

AU - Yañez, Matilde

AU - Marco-Contelles, José

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N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

Abstract

ASJC Scopus subject areas

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