NAC attenuates LPS-induced toxicity in aspirin-sensitized mouse macrophages via suppression of oxidative stress and mitochondrial dysfunction

Agriculture & Biology

• acetylcysteine 100%
• aspirin 92%
• lipopolysaccharides 74%
• macrophages 69%
• oxidative stress 60%
• toxicity 52%
• mice 44%
• apoptosis 11%
• reactive oxygen species 10%
• pretreatment 9%
• anti-inflammatory agents 8%
• endotoxins 7%
• catalytic activity 6%
• cytokines 6%
• cell death 5%
• glutathione 5%
• cell lines 4%
• antioxidants 4%
• cells 4%
• metabolism 3%
• synthesis 3%

Medicine & Life Sciences

• Cysteine 72%
• Aspirin 71%
• Lipopolysaccharides 66%
• Oxidative Stress 56%
• Macrophages 54%
• Reactive Oxygen Species 10%
• Cytochrome P-450 CYP2E1 8%
• Cytochrome P-450 CYP1A1 8%
• Apoptosis 7%
• Physiological Stress 7%
• Endotoxins 6%
• Oxidation-Reduction 6%
• Glutathione 5%
• Signal Transduction 5%
• Adenosine Triphosphate 5%
• Cell Death 4%
• Poisons 4%
• Antioxidants 4%
• Anti-Inflammatory Agents 4%
• Cytokines 3%
• Cell Line 3%
• In Vitro Techniques 2%
• Pharmaceutical Preparations 2%

Chemical Compounds

• Lipopolysaccharide 84%
• Oxidative Stress 76%
• Cysteine 66%
• Reactive Oxygen Metabolite 18%
• Acetylsalicylic Acid 12%
• Endotoxin 12%
• Anti-Inflammatory Drug 12%
• Apoptotic 11%
• Cell Death 10%
• Metabolic 7%
• Pharmacological Metabolism 7%
• Antioxidant Agent 7%