Nano-TiO2 enriched polymeric powder coatings support human mesenchymal cell attachment and growth

Mohammad Sayem Mozumder, Jesse Zhu, Hiran Perinpanayagam

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The objective of this study was to utilize ultrafine powder coating technology to prepare (PPC) that can support human mesenchymal cell attachment and growth. Resins were modified with titanium dioxide and polytetrafluoroethylene (PTFE), and enriched with either SiO2 or TiO2 nanoparticles (nSiO2 or nTiO2) to create continuous PPC. Scanning electron microscopy (SEM) revealed complex surface topographies with nano features, and energy dispersive X-ray (EDX) analysis with Ti mapping confirmed a homogenous dispersion of the material. SEM and inverted fluorescence microscopy showed that human embryonic palatal mesenchymal (HEPM) cells attached and spread out on the PPC surfaces, particularly those enriched with nTiO2. Cell counts were higher, and the MTT assay measured more metabolic activity from the nTiO2 enriched PPCs. Furthermore, these cellular responses were enhanced on PPC surfaces that were enriched with a higher concentration of nTiO2 (2% vs. 0.5%), and appeared comparable to that seen on commercially pure titanium (cpTi). Therefore the nTiO 2 enrichment of PPC was shown to favor human mesenchymal cell attachment and growth. Indeed, this modification of the materials created continuous surface coatings that sustained a favorable cellular response.

Original languageEnglish
Pages (from-to)173-193
Number of pages21
JournalJournal of Biomaterials Applications
Issue number2
Publication statusPublished - Aug 2011
Externally publishedYes


  • cell attachment
  • cytocompatibility.
  • nanoparticles
  • powder coating
  • titanium dioxide

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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