Nanomedicine-based cancer immunotherapy: recent trends and future perspectives

Vinoth Kumar Lakshmanan, Shlok Jindal, Gopinath Packirisamy, Shreesh Ojha, Sen Lian, Ajeet Kaushik, Abdulqadir Ismail M.Abdullah Alzarooni, Yasser Abdelraouf Farahat Metwally, Sadras Panchatcharam Thyagarajan, Young Do Jung, Salem Chouaib

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)


The combination of cancer immunotherapy with efficient functionalized nanosystems has emerged as a beneficial treatment strategy and its use has increased rapidly. The roles of stimuli-responsive nanosystems and nanomedicine-based cancer immunotherapy, a subsidiary discipline in the field of immunology, are pivotal. The present era is witnessing rapid advancements in the use of nanomedicine as a platform for investigating novel therapeutic applications and modern intelligent healthcare management strategies. The development of cancer nanomedicine has posthaste ratified the outcomes of immunotherapy to the subsequent stage in the current era of medical research. This review focuses on key findings with respect to the effectiveness of nanomedicine-based cancer immunotherapies and their applications, which include i) immune checkpoint inhibitors and nanomedicine, ii) CRISPR-Cas nanoparticles (NPs) in cancer immunotherapy, iii) combination cancer immunotherapy with core-shell nanoparticles, iv) biomimetic NPs for cancer immunotherapy, and v) CAR-T cells and cancer nanoimmunotherapy. By evaluating the state-of-the-art tools and taking the challenges involved into consideration, various aspects of the proposed nano-enabled therapeutic approaches have been discussed in this review.

Original languageEnglish
Pages (from-to)911-923
Number of pages13
JournalCancer Gene Therapy
Issue number9
Publication statusPublished - Sept 2021

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cancer Research


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