Nanoparticles rapidly assess specific IgE in plasma

Sarmadia Ashraf, Shahnaz Qadri, Basel Al-Ramadi, Yousef Haik

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Allergy is the sixth leading cause of chronic disease in the world. This study demonstrates the feasibility of detecting allergy indicators in human plasma, noninvasively, at the point of care and with a comparable efficiency and reduced turnaround time compared with the gold standard. Peanut allergy was utilized as a model due to its widespread occurrence among the US population and fatality if not treated. The detection procedure utilized magnetic nanoparticles that were coated with an allergen layer (peanut protein extract). Peanut immunoglobulin E (IgE) was detected in concentrations close to the minimum detection range of CAP assay. The results were obtained in minutes compared with the CAP assay which requires more than 3h.

Original languageEnglish
Article number305101
JournalNanotechnology
Volume23
Issue number30
DOIs
Publication statusPublished - Aug 3 2012

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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