Nanotheranostics to target antibiotic-resistant bacteria: Strategies and applications

Rahul Bhattacharjee, Arvind Negi, Basudha Bhattacharya, Tanima Dey, Priya Mitra, Subham Preetam, Lamha Kumar, Sulagna Kar, Sabya Sachi Das, Danish Iqbal, Mehnaz Kamal, Fayez Alghofaili, Sumira Malik, Abhijit Dey, Saurabh Kumar Jha, Shreesh Ojha, Ana Cláudia Paiva-Santos, Kavindra Kumar Kesari, Niraj Kumar Jha

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Various health agencies, such as the European Medical Agency (EMA), Centers for Disease Control and Prevention (CDC), and World Health Organization (WHO), timely cited the upsurge of antibiotic resistance as a severe threat to the public health and global economy. Importantly, there is a rise in nosocomial infections among covid-19 patients and in-hospitalized patients with the delineating disorder. Most of nosocomial infections are related to the bacteria residing in biofilm, which are commonly formed on material surfaces. In biofilms, microcolonies of various bacteria live in syntropy; therefore, their infections require a higher antibiotic dosage or cocktail of broad-spectrum antibiotics, aggravating the severity of antibiotic resistance. Notably, the lack of intrinsic antibacterial properties in commercial-grade materials desires to develop newer functionalized materials to prevent biofilm formation on their surfaces. To devise newer strategies, materials prepared at the nanoscale demonstrated reasonable antibacterial properties or enhanced the activity of antimicrobial agents (that are encapsulated/chemically functionalized onto the material surface). In this manuscript, we compiled such nanosized materials, specifying their role in targeting specific strains of bacteria. We also enlisted the examples of nanomaterials, nanodevice, nanomachines, nano-camouflaging, and nano-antibiotics for bactericidal activity and their possible clinical implications.

Original languageEnglish
Article number100138
Publication statusPublished - May 2023


  • Antibacterial
  • Antibiotic drug resistance
  • Nano-antibiotics
  • Nano-device
  • Nano-materials
  • Nano-robots
  • Nano-sized materials

ASJC Scopus subject areas

  • Internal Medicine
  • Biotechnology
  • Pharmaceutical Science
  • Pharmacology (medical)


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