NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates

A. Ghazawi; Á Sonnevend; R. A. Bonnin; L. Poirel; P. Nordmann; R. Hashmey; T. A. Rizvi; M. B Hamadeh; T. Pál

doi:10.1111/j.1469-0691.2011.03726.x

NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates

A. Ghazawi, Á Sonnevend, R. A. Bonnin, L. Poirel, P. Nordmann, R. Hashmey, T. A. Rizvi, M. B Hamadeh, T. Pál

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase bla_NDM gene-carrying isolates. They were isolated 4months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the bla_NDM-2 gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the bla_NDM-2 gene showed significant similarities with those associated with bla_NDM-1 in Enterobacteriaceae and A. baumannii. Repeated isolation of bla_NDM-2-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.

Original language	English
Pages (from-to)	E34-E36
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	2
DOIs	https://doi.org/10.1111/j.1469-0691.2011.03726.x
Publication status	Published - Feb 2012

Keywords

Acinetobacter
Carbapenemase
Middle East
Multidrug resistant
NDM-2

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1111/j.1469-0691.2011.03726.x

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title = "NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates",

abstract = "Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-{\ss}-lactamase blaNDM gene-carrying isolates. They were isolated 4months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the blaNDM-2 gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the blaNDM-2 gene showed significant similarities with those associated with blaNDM-1 in Enterobacteriaceae and A. baumannii. Repeated isolation of blaNDM-2-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.",

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author = "A. Ghazawi and {\'A} Sonnevend and Bonnin, {R. A.} and L. Poirel and P. Nordmann and R. Hashmey and Rizvi, {T. A.} and {B Hamadeh}, M. and T. P{\'a}l",

note = "Funding Information: This work was supported by UAEU grants 01-10-8-11/09 and 1439-08-02-10, FMHS grants NP/09/16 and NP/10/11/1019 and by the INSERM U914, France. ",

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AU - Sonnevend, Á

AU - Bonnin, R. A.

AU - Poirel, L.

AU - Nordmann, P.

AU - Hashmey, R.

AU - Rizvi, T. A.

AU - B Hamadeh, M.

AU - Pál, T.

N1 - Funding Information: This work was supported by UAEU grants 01-10-8-11/09 and 1439-08-02-10, FMHS grants NP/09/16 and NP/10/11/1019 and by the INSERM U914, France.

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N2 - Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase blaNDM gene-carrying isolates. They were isolated 4months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the blaNDM-2 gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the blaNDM-2 gene showed significant similarities with those associated with blaNDM-1 in Enterobacteriaceae and A. baumannii. Repeated isolation of blaNDM-2-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.

AB - Screening 155 carbapenem non-susceptible Acinetobacter baumannii strains recovered in Abu Dhabi hospitals identified two metallo-ß-lactamase blaNDM gene-carrying isolates. They were isolated 4months apart from the urine of a cancer patient previously treated in Egypt, Lebanon and in the United Arab Emirates. They were clonally related and carried the blaNDM-2 gene recently identified in A. baumannii in Egypt and Israel. Sequences surrounding the blaNDM-2 gene showed significant similarities with those associated with blaNDM-1 in Enterobacteriaceae and A. baumannii. Repeated isolation of blaNDM-2-positive A. baumannii in the Middle East raises the possibility of the local emergence and spread of a unique clone.

KW - Acinetobacter

KW - Carbapenemase

KW - Middle East

KW - Multidrug resistant

KW - NDM-2

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NDM-2 carbapenemase-producing Acinetobacter baumannii in the United Arab Emirates

Abstract

Keywords

ASJC Scopus subject areas

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