TY - JOUR
T1 - Nerve terminal morphology in C57BL/6NNia mice at different ages
AU - Andonian, M. H.
AU - Fahim, M. A.
PY - 1989
Y1 - 1989
N2 - The mammalian neuromuscular junction (NMJ) appears to undergo a dynamic remodeling process with advancing age. Previous studies suggest that the NMJ becomes progressively larger with age, to a greater degree in fast-twitch muscles than slow-twitch muscles. To better understand this process, quantitative morphometry was conducted on soleus and extensor digitorum longus (EDL) nerve terminals from C57BL/6NNia mice aged 4, 8, 10, 12, 18, 22, 24, and 32 months. Computer-aided morphometry of camera lucida drawings of aging nerve terminals indicated significant differences in the size and complexity of NMJs in both muscles between different age groups; however, there were no significant net trends with age. The magnitude and direction of the morphometric changes depended on the particular ages compared, and occurred to a greater degree in the EDL. This study is the first comprehensive morphometric study of C57BL/6NNia nerve terminals at so many ages. The results are simlar to those obtained for the Fischer 344 rat, and support the hypothesis that nerve terminal remodeling is a dynamic process, not a progressive elaboration.
AB - The mammalian neuromuscular junction (NMJ) appears to undergo a dynamic remodeling process with advancing age. Previous studies suggest that the NMJ becomes progressively larger with age, to a greater degree in fast-twitch muscles than slow-twitch muscles. To better understand this process, quantitative morphometry was conducted on soleus and extensor digitorum longus (EDL) nerve terminals from C57BL/6NNia mice aged 4, 8, 10, 12, 18, 22, 24, and 32 months. Computer-aided morphometry of camera lucida drawings of aging nerve terminals indicated significant differences in the size and complexity of NMJs in both muscles between different age groups; however, there were no significant net trends with age. The magnitude and direction of the morphometric changes depended on the particular ages compared, and occurred to a greater degree in the EDL. This study is the first comprehensive morphometric study of C57BL/6NNia nerve terminals at so many ages. The results are simlar to those obtained for the Fischer 344 rat, and support the hypothesis that nerve terminal remodeling is a dynamic process, not a progressive elaboration.
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U2 - 10.1093/geronj/44.2.b43
DO - 10.1093/geronj/44.2.b43
M3 - Article
C2 - 2921469
AN - SCOPUS:0024500394
SN - 0022-1422
VL - 44
SP - B43-51
JO - Journals of Gerontology
JF - Journals of Gerontology
IS - 2
ER -