Neural Substrates of the Drift-Diffusion Model in Brain Disorders

Ankur Gupta; Rohini Bansal; Hany Alashwal; Anil Safak Kacar; Fuat Balci; Ahmed A. Moustafa

doi:10.3389/fncom.2021.678232

Neural Substrates of the Drift-Diffusion Model in Brain Disorders

Ankur Gupta, Rohini Bansal, Hany Alashwal, Anil Safak Kacar, Fuat Balci, Ahmed A. Moustafa

Department of Computer Science and Software Engineering

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Many studies on the drift-diffusion model (DDM) explain decision-making based on a unified analysis of both accuracy and response times. This review provides an in-depth account of the recent advances in DDM research which ground different DDM parameters on several brain areas, including the cortex and basal ganglia. Furthermore, we discuss the changes in DDM parameters due to structural and functional impairments in several clinical disorders, including Parkinson's disease, Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorders, Obsessive-Compulsive Disorder (OCD), and schizophrenia. This review thus uses DDM to provide a theoretical understanding of different brain disorders.

Original language	English
Article number	678232
Journal	Frontiers in Computational Neuroscience
Volume	15
DOIs	https://doi.org/10.3389/fncom.2021.678232
Publication status	Published - Jan 7 2022

Keywords

basal ganglia
decision making
drift diffusion models
neural mechanism
prefrontal cortex

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Cellular and Molecular Neuroscience

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10.3389/fncom.2021.678232

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title = "Neural Substrates of the Drift-Diffusion Model in Brain Disorders",

abstract = "Many studies on the drift-diffusion model (DDM) explain decision-making based on a unified analysis of both accuracy and response times. This review provides an in-depth account of the recent advances in DDM research which ground different DDM parameters on several brain areas, including the cortex and basal ganglia. Furthermore, we discuss the changes in DDM parameters due to structural and functional impairments in several clinical disorders, including Parkinson's disease, Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorders, Obsessive-Compulsive Disorder (OCD), and schizophrenia. This review thus uses DDM to provide a theoretical understanding of different brain disorders.",

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AU - Balci, Fuat

AU - Moustafa, Ahmed A.

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N2 - Many studies on the drift-diffusion model (DDM) explain decision-making based on a unified analysis of both accuracy and response times. This review provides an in-depth account of the recent advances in DDM research which ground different DDM parameters on several brain areas, including the cortex and basal ganglia. Furthermore, we discuss the changes in DDM parameters due to structural and functional impairments in several clinical disorders, including Parkinson's disease, Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorders, Obsessive-Compulsive Disorder (OCD), and schizophrenia. This review thus uses DDM to provide a theoretical understanding of different brain disorders.

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Neural Substrates of the Drift-Diffusion Model in Brain Disorders

Abstract

Keywords

ASJC Scopus subject areas

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