Neuroanatomical Findings in Unipolar Depression and the Role of the Hippocampus

Depressive disorders are common conditions with a life prevalence of 15% in high-income countries (1) and significant economic implications for individuals and society. Major depressive disorders have negative repercussions on the overall quality of life of the people affected with an excess number of years lived with a disability (2). Although effective treatment is available, up to 65% of individuals do not fully respond or continue to experience residual symptoms, which contribute to significant disease burden (3). It is essential to improve our understanding of the neuroanatomy of depressive disorders and the functional implications to develop new targets for more efficacious treatments.