NEUROPEPTIDE TYROSINE (NPY)-A MAJOR CARDIAC NEUROPEPTIDE

J. Gu; T. E. Adrian; K. Tatemoto; J. M. Polak; J. M. Allen; S. R. Bloom

doi:10.1016/S0140-6736(83)92642-9

NEUROPEPTIDE TYROSINE (NPY)-A MAJOR CARDIAC NEUROPEPTIDE

J. Gu, T. E. Adrian, K. Tatemoto, J. M. Polak, J. M. Allen, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

165 Citations (Scopus)

Abstract

A newly discovered bioactive peptide, neuropeptide tyrosine (NPY), has been found in the human cardiac nervous system. Dense concentrations of NPY-immunoreactive nerve fibres were found in association with nodal tissue (atrioventricular node 22·1±3·7 pmol/g). NPY nerve fibres were seen in close contact with cardiac muscle fibres and were also found around the coronary vessels (19·6±6·2 pmol/g). Analysis of the peptide by high-performance liquid chromatography demonstrated that it was present in a single molecular form, closely similar or identical to that of the isolated bioactive peptide. Cardiac function in man has long been known to be influenced by cholinergic and adrenergic nerves. There now appears to be a further component of the nervous system in the human heart, involving peptidergic nerves containing NPY.

Original language	English
Pages (from-to)	1008-1010
Number of pages	3
Journal	The Lancet
Volume	321
Issue number	8332
DOIs	https://doi.org/10.1016/S0140-6736(83)92642-9
Publication status	Published - May 7 1983
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(83)92642-9

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@article{9103226fee234aad9be89cebf448ea58,

title = "NEUROPEPTIDE TYROSINE (NPY)-A MAJOR CARDIAC NEUROPEPTIDE",

abstract = "A newly discovered bioactive peptide, neuropeptide tyrosine (NPY), has been found in the human cardiac nervous system. Dense concentrations of NPY-immunoreactive nerve fibres were found in association with nodal tissue (atrioventricular node 22·1±3·7 pmol/g). NPY nerve fibres were seen in close contact with cardiac muscle fibres and were also found around the coronary vessels (19·6±6·2 pmol/g). Analysis of the peptide by high-performance liquid chromatography demonstrated that it was present in a single molecular form, closely similar or identical to that of the isolated bioactive peptide. Cardiac function in man has long been known to be influenced by cholinergic and adrenergic nerves. There now appears to be a further component of the nervous system in the human heart, involving peptidergic nerves containing NPY.",

author = "J. Gu and Adrian, {T. E.} and K. Tatemoto and Polak, {J. M.} and Allen, {J. M.} and Bloom, {S. R.}",

note = "Funding Information: This work was generously supported by grants from the British Diabetic Association and the British Heart Foundation. J. M. A. holds a Wellcome Trust Fellowship. J. G. is a visiting scholar from the Department of Pathology, Peking Medical College, Peking, China, and is financially supported by the Chinese Government.",

year = "1983",

month = may,

day = "7",

doi = "10.1016/S0140-6736(83)92642-9",

language = "English",

volume = "321",

pages = "1008--1010",

journal = "The Lancet",

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T1 - NEUROPEPTIDE TYROSINE (NPY)-A MAJOR CARDIAC NEUROPEPTIDE

AU - Gu, J.

AU - Adrian, T. E.

AU - Tatemoto, K.

AU - Polak, J. M.

AU - Allen, J. M.

AU - Bloom, S. R.

N1 - Funding Information: This work was generously supported by grants from the British Diabetic Association and the British Heart Foundation. J. M. A. holds a Wellcome Trust Fellowship. J. G. is a visiting scholar from the Department of Pathology, Peking Medical College, Peking, China, and is financially supported by the Chinese Government.

PY - 1983/5/7

Y1 - 1983/5/7

N2 - A newly discovered bioactive peptide, neuropeptide tyrosine (NPY), has been found in the human cardiac nervous system. Dense concentrations of NPY-immunoreactive nerve fibres were found in association with nodal tissue (atrioventricular node 22·1±3·7 pmol/g). NPY nerve fibres were seen in close contact with cardiac muscle fibres and were also found around the coronary vessels (19·6±6·2 pmol/g). Analysis of the peptide by high-performance liquid chromatography demonstrated that it was present in a single molecular form, closely similar or identical to that of the isolated bioactive peptide. Cardiac function in man has long been known to be influenced by cholinergic and adrenergic nerves. There now appears to be a further component of the nervous system in the human heart, involving peptidergic nerves containing NPY.

AB - A newly discovered bioactive peptide, neuropeptide tyrosine (NPY), has been found in the human cardiac nervous system. Dense concentrations of NPY-immunoreactive nerve fibres were found in association with nodal tissue (atrioventricular node 22·1±3·7 pmol/g). NPY nerve fibres were seen in close contact with cardiac muscle fibres and were also found around the coronary vessels (19·6±6·2 pmol/g). Analysis of the peptide by high-performance liquid chromatography demonstrated that it was present in a single molecular form, closely similar or identical to that of the isolated bioactive peptide. Cardiac function in man has long been known to be influenced by cholinergic and adrenergic nerves. There now appears to be a further component of the nervous system in the human heart, involving peptidergic nerves containing NPY.

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NEUROPEPTIDE TYROSINE (NPY)-A MAJOR CARDIAC NEUROPEPTIDE

Abstract

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