Neuropeptide Y distribution in the rat brain

Y. S. Allen; T. E. Adrian; J. M. Allen; K. Tatemoto; T. J. Crow; S. R. Bloom; J. M. Polak

doi:10.1126/science.6136091

Neuropeptide Y distribution in the rat brain

Y. S. Allen, T. E. Adrian, J. M. Allen, K. Tatemoto, T. J. Crow, S. R. Bloom, J. M. Polak

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Abstract

A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.

Original language	English
Pages (from-to)	877-879
Number of pages	3
Journal	Science
Volume	221
Issue number	4613
DOIs	https://doi.org/10.1126/science.6136091
Publication status	Published - 1983
Externally published	Yes

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title = "Neuropeptide Y distribution in the rat brain",

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author = "Allen, {Y. S.} and Adrian, {T. E.} and Allen, {J. M.} and K. Tatemoto and Crow, {T. J.} and Bloom, {S. R.} and Polak, {J. M.}",

year = "1983",

doi = "10.1126/science.6136091",

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AU - Allen, Y. S.

AU - Adrian, T. E.

AU - Allen, J. M.

AU - Tatemoto, K.

AU - Crow, T. J.

AU - Bloom, S. R.

AU - Polak, J. M.

PY - 1983

Y1 - 1983

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AB - A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.

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JO - Science

JF - Science

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ER -

Neuropeptide Y distribution in the rat brain

Abstract

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