Neuropeptide Y in human spinal cord

J. M. Allen, S. J. Gibson, T. E. Adrian, J. M. Polak, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

The distribution of a newly described peptide, neuropeptide Y (NPY) within the human spinal cord has been determined using radioimmunoassay and immunoccytochemistry. Higher concentrations were found in the lunar (49.9 ± 6.8 pmol/g) and sacral (47.0 ± 10.6 pmol/g) regions than in the cervical (27.6 ± 2.7 pmol/g) and thoracic spinal cord (33.8 |+- 5.3 pmol/g). Immunocytochemistry revealed numerous nerve fibers containing NPY in the spinal cord; these were particularly concentrated in the substantia gelatinosa of the dorsal horn. In the ventral spinal cord NPY-containing nerves were sparse becoming more abundant in lumbosacral segments.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalBrain Research
Volume308
Issue number1
DOIs
Publication statusPublished - Aug 6 1984
Externally publishedYes

Keywords

  • human spinal cord
  • immunocytochemistry
  • neuropeptide Y
  • radioimmunoassay

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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