@article{56d15f05b1f44a8ba73c03a4f33cea22,
title = "Neuropeptide Y in human spinal cord",
abstract = "The distribution of a newly described peptide, neuropeptide Y (NPY) within the human spinal cord has been determined using radioimmunoassay and immunoccytochemistry. Higher concentrations were found in the lunar (49.9 ± 6.8 pmol/g) and sacral (47.0 ± 10.6 pmol/g) regions than in the cervical (27.6 ± 2.7 pmol/g) and thoracic spinal cord (33.8 |+- 5.3 pmol/g). Immunocytochemistry revealed numerous nerve fibers containing NPY in the spinal cord; these were particularly concentrated in the substantia gelatinosa of the dorsal horn. In the ventral spinal cord NPY-containing nerves were sparse becoming more abundant in lumbosacral segments.",
keywords = "human spinal cord, immunocytochemistry, neuropeptide Y, radioimmunoassay",
author = "Allen, {J. M.} and Gibson, {S. J.} and Adrian, {T. E.} and Polak, {J. M.} and Bloom, {S. R.}",
note = "Funding Information: 1 Allen, J, M., Adrian,T . E., TatemotoK, ., Polak, J. M., HughesJ,. and Bloom,S . R., Two novelr elatedp eptides, neuropeptidYe (NPY) and peptideY Y (PYY) inhibitt he contractioonf the electricallsyt imulatemd ousev as defe-rens,N europeptide3s, ( 1982)7 1-77. 2 Allen, J. M., BirchamP, . M. M., EdwardsA, . V., Tatemo-to, K. and Bloom, S. R., NeuropeptidYe (NPY) reduces myocardiaple rfusiona nd inhibitst he forceo f contraction of the isolatedp erfusedr abbit heart. Regulat. Pept., 6 (1983)2 47-254. 3 Allen, J. M., McGregorG, . P., Adrian.T . E., Bloom, S R., Zjang,S . Q., Ennis,K . W. and Unger,W . G., Reduc-tion of neuropeptidYe (NPY) in the rabbitir is ciliaryb ody following sympathectomEy,r p. Eye Res.. 37 (t983) 213-215. 4 Allen, Y. S., Adrian,T . E., Allen, J. M., TatemotoK, ., Crow, T. J., Bloom,S . R. and Polak,J . M., Neuropeptide Y distributioinn rat brain,S cience2, 21( 198318 77-879. 5 Allen, Y. S., Crow, T. J., TatemotoK, . and Polak,J . M., Co-storagoef a noveln europeptidnee, uropeptidYe with catecholaminiens t he rat locusc oeruleusP,r oc. Roy, Mi-croscop.S oc., 18( 198312 , 77. 6 Gibson,S . J., Polak,J . M., Bloom,S . R. and Wall, P. D,, The distributioonf ninep eptideisn rat spinalc ordw iths pe-cial emphasiosn the substantigae latinosaan don the area aroundth ec entracl anal( LaminaX ), J. comp. Neurol., 201 (1981)6 5-79. 7 Gibson,S . J., Polak, J. M,, Adrian, T. E., Allen, J. M.. Kelly, J, S. andB loom,S . R., The distributioann do rigino t J.M.A. is in receipto f a Wellcomc llrust 1r amm.t Fellowshipa nd this work was additionallysu ppor!ed by the Wellcome Trust (grant ~_~ Profess<itP-. 13 Wall) and the SpasticsS ocietyNPY was agc,n erous gift from Dr. K. Tatemoto, karolinska lt~stmttc Stockhohn.",
year = "1984",
month = aug,
day = "6",
doi = "10.1016/0006-8993(84)90926-0",
language = "English",
volume = "308",
pages = "145--148",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}