NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS

T. E. Adrian; G. Terenghi; M. J. Brown; J. M. Allen; A. J. Bacarese-Hamilton; J. M. Polak; S. R. Bloom

doi:10.1016/S0140-6736(83)90570-6

NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS

T. E. Adrian, G. Terenghi, M. J. Brown, J. M. Allen, A. J. Bacarese-Hamilton, J. M. Polak, S. R. Bloom

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138 Citations (Scopus)

Abstract

Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straighforward to measure and relatively stable, its estimation may prove helpful as a screening test for phaeochromocytoma.

Original language	English
Pages (from-to)	540-542
Number of pages	3
Journal	The Lancet
Volume	322
Issue number	8349
DOIs	https://doi.org/10.1016/S0140-6736(83)90570-6
Publication status	Published - Sept 3 1983
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(83)90570-6

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@article{0b9cc93328044844862ceaeb1cc67527,

title = "NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS",

abstract = "Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straighforward to measure and relatively stable, its estimation may prove helpful as a screening test for phaeochromocytoma.",

author = "Adrian, {T. E.} and G. Terenghi and Brown, {M. J.} and Allen, {J. M.} and Bacarese-Hamilton, {A. J.} and Polak, {J. M.} and Bloom, {S. R.}",

note = "Funding Information: We thank the ultrasonographers from the Department of Radiology at the Queen Elizabeth Hospital; Sister Carol Hanna and Sister Anne Moschou; the obstetric nursing staff; Leila Mak and Leanne Hourigan, for the endrocrine assays; and Del Crowe of the Department of Reproductive Medicine, University of California, San Diego, for typing the manuscript. This study was supported m part by National Health and Medical Research Council Grant 810549.",

year = "1983",

month = sep,

day = "3",

doi = "10.1016/S0140-6736(83)90570-6",

language = "English",

volume = "322",

pages = "540--542",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "8349",

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TY - JOUR

T1 - NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS

AU - Adrian, T. E.

AU - Terenghi, G.

AU - Brown, M. J.

AU - Allen, J. M.

AU - Bacarese-Hamilton, A. J.

AU - Polak, J. M.

AU - Bloom, S. R.

N1 - Funding Information: We thank the ultrasonographers from the Department of Radiology at the Queen Elizabeth Hospital; Sister Carol Hanna and Sister Anne Moschou; the obstetric nursing staff; Leila Mak and Leanne Hourigan, for the endrocrine assays; and Del Crowe of the Department of Reproductive Medicine, University of California, San Diego, for typing the manuscript. This study was supported m part by National Health and Medical Research Council Grant 810549.

PY - 1983/9/3

Y1 - 1983/9/3

N2 - Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straighforward to measure and relatively stable, its estimation may prove helpful as a screening test for phaeochromocytoma.

AB - Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straighforward to measure and relatively stable, its estimation may prove helpful as a screening test for phaeochromocytoma.

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SN - 0140-6736

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JO - The Lancet

JF - The Lancet

IS - 8349

ER -

NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS

Abstract

ASJC Scopus subject areas

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