Neuropeptide Y Levels During Ischemia and Reperfusion in the Canine Infrarenal Aortic Revascularization Model

John D. Edwards; Peter S. Dovgan; Jane M. Rowley; Patricia E. Thorpe; Thomas E. Adrian; Devendra K. Agrawal

doi:10.1007/BF02132996

Neuropeptide Y Levels During Ischemia and Reperfusion in the Canine Infrarenal Aortic Revascularization Model

John D. Edwards, Peter S. Dovgan, Jane M. Rowley, Patricia E. Thorpe, Thomas E. Adrian, Devendra K. Agrawal

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel do after infrarenal aortic cross-clampin. We found a two-to threefold increase in NPY Levels during ischemia (intial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p <0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p <0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

Original language	English
Pages (from-to)	350-355
Number of pages	6
Journal	Annals of Vascular Surgery
Volume	8
Issue number	4
DOIs	https://doi.org/10.1007/BF02132996
Publication status	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Surgery
Cardiology and Cardiovascular Medicine

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10.1007/BF02132996

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@article{cd97b4c97a154903ae3d29e2859b64f6,

title = "Neuropeptide Y Levels During Ischemia and Reperfusion in the Canine Infrarenal Aortic Revascularization Model",

abstract = "Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel do after infrarenal aortic cross-clampin. We found a two-to threefold increase in NPY Levels during ischemia (intial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p <0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p <0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.",

author = "Edwards, {John D.} and Dovgan, {Peter S.} and Rowley, {Jane M.} and Thorpe, {Patricia E.} and Adrian, {Thomas E.} and Agrawal, {Devendra K.}",

note = "Funding Information: From the Creighton Vascular Center, Departments of Surgery, Radiology (P.E.T.), and Biomedical Science (T.E.A.), Creighton University School of Medicine, Omaha, Neb. Supported by a grant from the Health Future Foundation. Reprint requests: John D. Edwards, MD, Chief. Vascular Surgery, Creighton University School of Medicine, 601 N. 30th St., Omaha, NE 68131.",

year = "1994",

doi = "10.1007/BF02132996",

language = "English",

volume = "8",

pages = "350--355",

journal = "Annals of Vascular Surgery",

issn = "0890-5096",

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T1 - Neuropeptide Y Levels During Ischemia and Reperfusion in the Canine Infrarenal Aortic Revascularization Model

AU - Edwards, John D.

AU - Dovgan, Peter S.

AU - Rowley, Jane M.

AU - Thorpe, Patricia E.

AU - Adrian, Thomas E.

AU - Agrawal, Devendra K.

N1 - Funding Information: From the Creighton Vascular Center, Departments of Surgery, Radiology (P.E.T.), and Biomedical Science (T.E.A.), Creighton University School of Medicine, Omaha, Neb. Supported by a grant from the Health Future Foundation. Reprint requests: John D. Edwards, MD, Chief. Vascular Surgery, Creighton University School of Medicine, 601 N. 30th St., Omaha, NE 68131.

PY - 1994

Y1 - 1994

N2 - Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel do after infrarenal aortic cross-clampin. We found a two-to threefold increase in NPY Levels during ischemia (intial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p <0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p <0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

AB - Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel do after infrarenal aortic cross-clampin. We found a two-to threefold increase in NPY Levels during ischemia (intial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p <0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p <0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

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Neuropeptide Y Levels During Ischemia and Reperfusion in the Canine Infrarenal Aortic Revascularization Model

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