Neuropeptides and leukotriene biosynthesis: The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin

Vincenzo Di Marzo; John R. Tippins; Sehamuddin H.I. Galadari; Howard R. Morris

doi:10.1016/0143-4179(88)90071-6

Neuropeptides and leukotriene biosynthesis: The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin

Vincenzo Di Marzo
, John R. Tippins
, Sehamuddin H.I. Galadari
, Howard R. Morris

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The effect of five neuropeptides was tested on platelet activating factor (PAF)-stimulated peptidoleukotriene biosynthesis in rat lungs. Calcitonin and peptide histidine valine-42 (PHV-42) were found to inhibit leukotriene C₄ (LTC₄) and D₄ (LTD₄) biosynthesis to an extent similar to the previously reported effects of calcitonin gene-related peptide (CGRP) and peptide histidine isoleucine (PHI) respectively. Helodermin potently inhibited the biosynthesis of all three peptidoleukotrienes. Neuropeptide Y and galanin, both present in airways, enhanced the levels of LTD₄ and had no effect on LTC₄ or leukotriene E₄ (LTE₄) levels. The theoretical implications of these findings are discussed.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	Neuropeptides
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/0143-4179(88)90071-6
Publication status	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Neurology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1016/0143-4179(88)90071-6

Cite this

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title = "Neuropeptides and leukotriene biosynthesis: The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin",

abstract = "The effect of five neuropeptides was tested on platelet activating factor (PAF)-stimulated peptidoleukotriene biosynthesis in rat lungs. Calcitonin and peptide histidine valine-42 (PHV-42) were found to inhibit leukotriene C4 (LTC4) and D4 (LTD4) biosynthesis to an extent similar to the previously reported effects of calcitonin gene-related peptide (CGRP) and peptide histidine isoleucine (PHI) respectively. Helodermin potently inhibited the biosynthesis of all three peptidoleukotrienes. Neuropeptide Y and galanin, both present in airways, enhanced the levels of LTD4 and had no effect on LTC4 or leukotriene E4 (LTE4) levels. The theoretical implications of these findings are discussed.",

author = "\{Di Marzo\}, Vincenzo and Tippins, \{John R.\} and Galadari, \{Sehamuddin H.I.\} and Morris, \{Howard R.\}",

year = "1988",

doi = "10.1016/0143-4179(88)90071-6",

language = "English",

volume = "11",

pages = "169--172",

journal = "Neuropeptides",

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T1 - Neuropeptides and leukotriene biosynthesis

T2 - The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin

AU - Di Marzo, Vincenzo

AU - Tippins, John R.

AU - Galadari, Sehamuddin H.I.

AU - Morris, Howard R.

PY - 1988

Y1 - 1988

N2 - The effect of five neuropeptides was tested on platelet activating factor (PAF)-stimulated peptidoleukotriene biosynthesis in rat lungs. Calcitonin and peptide histidine valine-42 (PHV-42) were found to inhibit leukotriene C4 (LTC4) and D4 (LTD4) biosynthesis to an extent similar to the previously reported effects of calcitonin gene-related peptide (CGRP) and peptide histidine isoleucine (PHI) respectively. Helodermin potently inhibited the biosynthesis of all three peptidoleukotrienes. Neuropeptide Y and galanin, both present in airways, enhanced the levels of LTD4 and had no effect on LTC4 or leukotriene E4 (LTE4) levels. The theoretical implications of these findings are discussed.

AB - The effect of five neuropeptides was tested on platelet activating factor (PAF)-stimulated peptidoleukotriene biosynthesis in rat lungs. Calcitonin and peptide histidine valine-42 (PHV-42) were found to inhibit leukotriene C4 (LTC4) and D4 (LTD4) biosynthesis to an extent similar to the previously reported effects of calcitonin gene-related peptide (CGRP) and peptide histidine isoleucine (PHI) respectively. Helodermin potently inhibited the biosynthesis of all three peptidoleukotrienes. Neuropeptide Y and galanin, both present in airways, enhanced the levels of LTD4 and had no effect on LTC4 or leukotriene E4 (LTE4) levels. The theoretical implications of these findings are discussed.

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UR - https://www.scopus.com/pages/publications/0023897449#tab=citedBy

U2 - 10.1016/0143-4179(88)90071-6

DO - 10.1016/0143-4179(88)90071-6

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AN - SCOPUS:0023897449

SN - 0143-4179

VL - 11

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JO - Neuropeptides

JF - Neuropeptides

IS - 4

ER -

Neuropeptides and leukotriene biosynthesis: The effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin

Abstract

ASJC Scopus subject areas

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