Neuropilins: C-end rule peptides and their association with nociception and COVID-19

Amie Jobe, Ranjit Vijayan

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2). Considering the disparities in the transmission rate and viral tropism of the two coronaviruses, additional host factors were suspected. Recently, a novel host factor for SARS-CoV-2 entry, neuropilin-1 (NRP-1) has been identified. These receptors potentiate viral infection in the presence of other host factors like ACE2. Through its C-end rule (CendR) motif exposed following furin processing, the SARS-CoV-2 spike protein binds to the CendR pocket of NRP-1 and achieves cell entry through endocytosis. The binding of SARS-CoV-2 spike protein to the NRP-1 receptor interferes with the docking of its endogenous ligand VEGF-A, signaling that would otherwise promote nociception. This review looks at the function of neuropilins and how it contributes to SARS-CoV-2 infection and nociception.

Original languageEnglish
Pages (from-to)1889-1895
Number of pages7
JournalComputational and Structural Biotechnology Journal
Publication statusPublished - Jan 2021


  • Host factor
  • Neuropilin
  • Nociception
  • SARS-CoV-2
  • Spike protein
  • VEGF-A

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Computer Science Applications


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