Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F1α and F2α with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.
|Number of pages||6|
|Journal||European Journal of Pharmacology|
|Publication status||Published - Dec 13 1988|
- Neuromedin N
- Stomach (guinea-pig)
ASJC Scopus subject areas