Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach

Stavros Katsoulis; J. Michael Conlon

doi:10.1016/0014-2999(88)90074-X

Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach

Stavros Katsoulis, J. Michael Conlon

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E₁, E₂, F_1α and F_2α with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	European Journal of Pharmacology
Volume	158
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(88)90074-X
Publication status	Published - Dec 13 1988
Externally published	Yes

Keywords

Neuromedin N
Neurotensin
Prostaglandins
Stomach (guinea-pig)
Xenopsin

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(88)90074-X

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title = "Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach",

abstract = "Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F1α and F2α with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.",

keywords = "Neuromedin N, Neurotensin, Prostaglandins, Stomach (guinea-pig), Xenopsin",

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doi = "10.1016/0014-2999(88)90074-X",

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T1 - Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach

AU - Katsoulis, Stavros

AU - Conlon, J. Michael

PY - 1988/12/13

Y1 - 1988/12/13

N2 - Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F1α and F2α with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.

AB - Neurotensin, xenopsin and neuromedin N had a biphasic effect (initial small relaxation followed by a sustained contraction) on the motility of longitudinal muscle strips from the guinea pig gastric corpus. Kinetensin was without effect. Tetrodotoxin, adrenaline, histamine, 5-hydroxytryptamine, opioid peptides, angiotensin II and antagonists of acetylcholine, and desensitization of the strips to bradykinin did not modify the action of neurotensin. The contraction phase was inhibited in a concentration-dependent manner by indomethacin and acetylsalicylate, demonstrating that this activity of neurotensin was dependent on prostaglandin synthesis. The preparation responded to exogenous prostaglandins E1, E2, F1α and F2α with concentration-dependent contractions. The relaxation phase was abolished by verapamil and apamin, indicating the presence of inhibitory neurotensin receptors on smooth muscle cells that are linked to ionic channels.

KW - Neuromedin N

KW - Neurotensin

KW - Prostaglandins

KW - Stomach (guinea-pig)

KW - Xenopsin

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VL - 158

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Neurotensin and prostaglandin interactions in smooth muscle of the guinea pig stomach

Abstract

Keywords

ASJC Scopus subject areas

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