@article{290b3d1cb45248139819663eda0445ea,
title = "Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations",
abstract = "Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.",
author = "Robinson, {Harriet L.} and Montefiori, {David C.} and Johnson, {R. Paul} and Manson, {Kelledy H.} and Kalish, {Marcia L.} and Lifson, {Jeffrey D.} and Rizvi, {Tahir A.} and Shan Lu and Hu, {Shiu Lok} and Mazzara, {Gail P.} and Panicali, {Dennis L.} and Herndon, {James G.} and Rhona Glickman and Candido, {Maria A.} and Lydy, {Shari L.} and Wyand, {Michael S.} and McClure, {Harold M.}",
note = "Funding Information: Acknowledgments We thank M. Feinberg and J. Safrit for critical comments on the manuscript. We are indebted to H. Drake-Perrow for administrative assistance. We thank M. Piatak, L. Li, and T. Parks for assistance with SIV RNA viral load analysis; J. Yang for assistance with T-cell assays; R. Schmidt for help in construction of pRS102; and A. Saekhou for assistance with analyses of transferred virus. This research was supported by NIH grants R01-AI-34241 and P01-AI-43045 (H.L.R.); R01-AI-40334 (S.L.); P01-AI-26503 (S.-L.H.) R01 AI 52634, RR 000138 (R. P. Johnson) and U01 AI 26507 (D.L.P.); by the Yerkes Primate Research Center Base Grant, RR-00165; and by contracts NCI-6S-1649 (D.C.M.) and NO1-CO-56000 (J.D.L.). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.",
year = "1999",
month = may,
doi = "10.1038/8406",
language = "English",
volume = "5",
pages = "526--534",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "5",
}