New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights

M. Shaheer Malik, Reem I. Alsantali, Qazi Mohammad Sajid Jamal, Zaki S. Seddigi, Moataz Morad, Meshari A. Alsharif, Essam M. Hussein, Rabab S. Jassas, Munirah M. Al-Rooqi, Zainularifeen Abduljaleel, Ahmed O. Babalgith, Hatem M. Altass, Ziad Moussa, Saleh A. Ahmed

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

An efficient atom-economical synthetic protocol to access new imidazole-based N-phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized to provide a series of N-phenylbenzamide derivatives in a short reaction time (2–4 h) with an 80–85% yield. The cytotoxic evaluation revealed that derivatives 4e and 4f exhibited good activity, with IC50 values between 7.5 and 11.1 μM against the tested cancer cell lines. Computational studies revealed interesting insights: the docking of the active derivatives (4e and 4f) showed a higher affinity toward the target receptor protein than the control. Molecular dynamic simulations revealed that the active derivatives form stable complexes with the ABL1 kinase protein. Moreover, the ADME and drug-likeness of the derivatives reinforced the potential of the derivatives to be taken up for further development as anticancer agents.

Original languageEnglish
Article number808556
JournalFrontiers in Chemistry
Volume9
DOIs
Publication statusPublished - Jan 19 2022

Keywords

  • ADME and drug-likeness
  • N-phenylbenzamide
  • anticancer activity
  • computational studies
  • imidazole
  • molecular dynamic simulations
  • multicomponent reaction

ASJC Scopus subject areas

  • Chemistry(all)

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