TY - GEN
T1 - New members of the interleukin-12 family of cytokines
T2 - IL-23 and IL-27 modulate autoimmune diabetes
AU - Mensah-Brown, E. P.K.
AU - Shahin, A.
AU - Al-Shamsi, M.
AU - Lukic, M. L.
PY - 2006/10
Y1 - 2006/10
N2 - Multiple low doses of streptozotocin (5 x 40 mg/kg) given to susceptible male C57BL6 mice induced delayed and sustained hyperglycemia accompanied by body weight loss, mononuclear cell infiltration in the islet, and apoptosis of b cells. Shorter regimes (4 x 40 mg/kg) did not have such effect. Administration of IL-23 at a dose of 400 ng/mL for 10 consecutive days concomitantly with this subdiabetogenic regimen of STZ, however, induced significant hyperglycemia, weight loss, and mononuclear cellular infiltration. The same regimen of IL-27 induced milder effect on glycemia and no weight loss inspite of a massive peri-islet and intra-islet infiltration of mononuclear cells. The molecular mechanisms underlying the actions of these cytokines on diabetogenesis is under study.
AB - Multiple low doses of streptozotocin (5 x 40 mg/kg) given to susceptible male C57BL6 mice induced delayed and sustained hyperglycemia accompanied by body weight loss, mononuclear cell infiltration in the islet, and apoptosis of b cells. Shorter regimes (4 x 40 mg/kg) did not have such effect. Administration of IL-23 at a dose of 400 ng/mL for 10 consecutive days concomitantly with this subdiabetogenic regimen of STZ, however, induced significant hyperglycemia, weight loss, and mononuclear cellular infiltration. The same regimen of IL-27 induced milder effect on glycemia and no weight loss inspite of a massive peri-islet and intra-islet infiltration of mononuclear cells. The molecular mechanisms underlying the actions of these cytokines on diabetogenesis is under study.
KW - Diabetes
KW - Interferon-g
KW - Interleukin-17
KW - Interleukin-23
KW - Interleukin-27
UR - http://www.scopus.com/inward/record.url?scp=33845712953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845712953&partnerID=8YFLogxK
U2 - 10.1196/annals.1375.024
DO - 10.1196/annals.1375.024
M3 - Conference contribution
C2 - 17130548
AN - SCOPUS:33845712953
SN - 1573316415
SN - 9781573316415
T3 - Annals of the New York Academy of Sciences
SP - 157
EP - 160
BT - Immunology of Diabetes IV
PB - Blackwell Publishing Inc.
ER -