New members of the interleukin-12 family of cytokines: IL-23 and IL-27 modulate autoimmune diabetes

E. P.K. Mensah-Brown, A. Shahin, M. Al-Shamsi, M. L. Lukic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)


Multiple low doses of streptozotocin (5 x 40 mg/kg) given to susceptible male C57BL6 mice induced delayed and sustained hyperglycemia accompanied by body weight loss, mononuclear cell infiltration in the islet, and apoptosis of b cells. Shorter regimes (4 x 40 mg/kg) did not have such effect. Administration of IL-23 at a dose of 400 ng/mL for 10 consecutive days concomitantly with this subdiabetogenic regimen of STZ, however, induced significant hyperglycemia, weight loss, and mononuclear cellular infiltration. The same regimen of IL-27 induced milder effect on glycemia and no weight loss inspite of a massive peri-islet and intra-islet infiltration of mononuclear cells. The molecular mechanisms underlying the actions of these cytokines on diabetogenesis is under study.

Original languageEnglish
Title of host publicationImmunology of Diabetes IV
Subtitle of host publicationProgress in Our Understanding
PublisherBlackwell Publishing Inc.
Number of pages4
ISBN (Print)1573316415, 9781573316415
Publication statusPublished - Oct 2006

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Diabetes
  • Interferon-g
  • Interleukin-17
  • Interleukin-23
  • Interleukin-27

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science


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