TY - JOUR
T1 - NON‐POSTURAL SERIAL CHANGES IN RENAL FUNCTION DURING THE THIRD TRIMESTER OF NORMAL HUMAN PREGNANCY
AU - Ezimokhai, M.
AU - Davison, J. M.
AU - Philips, P. R.
AU - Dunlop, W.
PY - 1981/5
Y1 - 1981/5
N2 - Seventeen healthy women were investigated near the beginning and again near the end of the third trimester of their normal pregnancies. Infusion studies were performed in the left lateral position. There was a highly significant decrease in effective renal plasma flow but not in glomerular filtration rate, measured as inulin clearance. Plasma creatinine concentration increased significantly, but the renal handling of creatinine was unchanged; simultaneous 24‐hour creatinine clearance showed a tendency to decrease. Serum urate concentration also increased significantly, apparently due to an increase in net tubular reabsorption of urate.
AB - Seventeen healthy women were investigated near the beginning and again near the end of the third trimester of their normal pregnancies. Infusion studies were performed in the left lateral position. There was a highly significant decrease in effective renal plasma flow but not in glomerular filtration rate, measured as inulin clearance. Plasma creatinine concentration increased significantly, but the renal handling of creatinine was unchanged; simultaneous 24‐hour creatinine clearance showed a tendency to decrease. Serum urate concentration also increased significantly, apparently due to an increase in net tubular reabsorption of urate.
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U2 - 10.1111/j.1471-0528.1981.tb01018.x
DO - 10.1111/j.1471-0528.1981.tb01018.x
M3 - Article
C2 - 7236549
AN - SCOPUS:0019404475
SN - 1470-0328
VL - 88
SP - 465
EP - 471
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 5
ER -