Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease

Alejandro Romero; Ramón Cacabelos; María J. Oset-Gasque; Abdelouahid Samadi; José Marco-Contelles

doi:10.1016/j.bmcl.2013.02.017

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease

Alejandro Romero, Ramón Cacabelos, María J. Oset-Gasque, Abdelouahid Samadi, José Marco-Contelles

Research output: Contribution to journal › Review article › peer-review

151 Citations (Scopus)

Abstract

A summary of the recently published efforts on tacrine derivatives as a renewed potential therapeutic approach for the treatment of Alzheimer's disease is presented.

Original language	English
Pages (from-to)	1916-1922
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2013.02.017
Publication status	Published - Apr 1 2013
Externally published	Yes

Keywords

Alzheimer's disease
Cholinesterase inhibitors
Hepatotoxicity
Multi-target-directed ligands
New tacrine hybrids
Tacrine

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.02.017

Cite this

@article{131082e9703547a987be875bc55f6550,

title = "Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease",

abstract = "A summary of the recently published efforts on tacrine derivatives as a renewed potential therapeutic approach for the treatment of Alzheimer's disease is presented.",

keywords = "Alzheimer's disease, Cholinesterase inhibitors, Hepatotoxicity, Multi-target-directed ligands, New tacrine hybrids, Tacrine",

author = "Alejandro Romero and Ram{\'o}n Cacabelos and Oset-Gasque, {Mar{\'i}a J.} and Abdelouahid Samadi and Jos{\'e} Marco-Contelles",

note = "Funding Information: J. Marco-Contelles thanks MICINN (SAF2006-08764-C02-01; SAF2009-07271; SAF2012-33304), AECID (Ministerio de Asuntos Exteriores (Spain) for the Grant {\textquoteleft}Acci{\'o}n Integrada (A1/035457/11){\textquoteright} with Tunisia. M. J. Oset-Gasque thanks MICINN (SAF2010-20337) and UCM-Santander (GR35/10-B) for financial support. J Marco-Contelles thanks Professor L. V. Modolo for sending us a reprint of her communication (Ref. 17a in this manuscript).",

year = "2013",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2013.02.017",

language = "English",

volume = "23",

pages = "1916--1922",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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number = "7",

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TY - JOUR

T1 - Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease

AU - Romero, Alejandro

AU - Cacabelos, Ramón

AU - Oset-Gasque, María J.

AU - Samadi, Abdelouahid

AU - Marco-Contelles, José

N1 - Funding Information: J. Marco-Contelles thanks MICINN (SAF2006-08764-C02-01; SAF2009-07271; SAF2012-33304), AECID (Ministerio de Asuntos Exteriores (Spain) for the Grant ‘Acción Integrada (A1/035457/11)’ with Tunisia. M. J. Oset-Gasque thanks MICINN (SAF2010-20337) and UCM-Santander (GR35/10-B) for financial support. J Marco-Contelles thanks Professor L. V. Modolo for sending us a reprint of her communication (Ref. 17a in this manuscript).

PY - 2013/4/1

Y1 - 2013/4/1

N2 - A summary of the recently published efforts on tacrine derivatives as a renewed potential therapeutic approach for the treatment of Alzheimer's disease is presented.

AB - A summary of the recently published efforts on tacrine derivatives as a renewed potential therapeutic approach for the treatment of Alzheimer's disease is presented.

KW - Alzheimer's disease

KW - Cholinesterase inhibitors

KW - Hepatotoxicity

KW - Multi-target-directed ligands

KW - New tacrine hybrids

KW - Tacrine

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DO - 10.1016/j.bmcl.2013.02.017

M3 - Review article

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SN - 0960-894X

VL - 23

SP - 1916

EP - 1922

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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