Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease

Alejandro Romero, Ramón Cacabelos, María J. Oset-Gasque, Abdelouahid Samadi, José Marco-Contelles

Research output: Contribution to journalReview articlepeer-review

132 Citations (Scopus)

Abstract

A summary of the recently published efforts on tacrine derivatives as a renewed potential therapeutic approach for the treatment of Alzheimer's disease is presented.

Original languageEnglish
Pages (from-to)1916-1922
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number7
DOIs
Publication statusPublished - Apr 1 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Cholinesterase inhibitors
  • Hepatotoxicity
  • Multi-target-directed ligands
  • New tacrine hybrids
  • Tacrine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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