Numerical computations of factor Xa and thrombin productions using a finite-volume method

John C. Chai; T. M. Tsai; Ji Jinn Foo; Vincent Chan

doi:10.1016/S0017-9310(01)00197-1

Numerical computations of factor Xa and thrombin productions using a finite-volume method

John C. Chai, T. M. Tsai, Ji Jinn Foo, Vincent Chan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The formations of Factor Xa and thrombin, two intermediate chemicals leading to the formation of blood clots in damaged blood vessels are predicted in this paper using a finite-volume method. The steady-state forms of the continuity, momentum and concentration equations are solved. The surface reactions are modeled using the classical Michaelis-Menten reaction kinetics. The results are compared with three sets of experimental data. These experiments were conducted using circular tubes and parallel flat plates. The present computational model is able to predict experimental results very well over a range of shear rates and inlet concentrations.

Original language	English
Pages (from-to)	785-792
Number of pages	8
Journal	International Journal of Heat and Mass Transfer
Volume	45
Issue number	4
DOIs	https://doi.org/10.1016/S0017-9310(01)00197-1
Publication status	Published - Dec 18 2001
Externally published	Yes

ASJC Scopus subject areas

Condensed Matter Physics
Mechanical Engineering
Fluid Flow and Transfer Processes

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10.1016/S0017-9310(01)00197-1

Cite this

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abstract = "The formations of Factor Xa and thrombin, two intermediate chemicals leading to the formation of blood clots in damaged blood vessels are predicted in this paper using a finite-volume method. The steady-state forms of the continuity, momentum and concentration equations are solved. The surface reactions are modeled using the classical Michaelis-Menten reaction kinetics. The results are compared with three sets of experimental data. These experiments were conducted using circular tubes and parallel flat plates. The present computational model is able to predict experimental results very well over a range of shear rates and inlet concentrations.",

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AU - Chai, John C.

AU - Tsai, T. M.

AU - Jinn Foo, Ji

AU - Chan, Vincent

PY - 2001/12/18

Y1 - 2001/12/18

N2 - The formations of Factor Xa and thrombin, two intermediate chemicals leading to the formation of blood clots in damaged blood vessels are predicted in this paper using a finite-volume method. The steady-state forms of the continuity, momentum and concentration equations are solved. The surface reactions are modeled using the classical Michaelis-Menten reaction kinetics. The results are compared with three sets of experimental data. These experiments were conducted using circular tubes and parallel flat plates. The present computational model is able to predict experimental results very well over a range of shear rates and inlet concentrations.

AB - The formations of Factor Xa and thrombin, two intermediate chemicals leading to the formation of blood clots in damaged blood vessels are predicted in this paper using a finite-volume method. The steady-state forms of the continuity, momentum and concentration equations are solved. The surface reactions are modeled using the classical Michaelis-Menten reaction kinetics. The results are compared with three sets of experimental data. These experiments were conducted using circular tubes and parallel flat plates. The present computational model is able to predict experimental results very well over a range of shear rates and inlet concentrations.

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JF - International Journal of Heat and Mass Transfer

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ER -

Numerical computations of factor Xa and thrombin productions using a finite-volume method

Abstract

ASJC Scopus subject areas

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