TY - JOUR
T1 - Nutraceutical and bioactive potential of high-quality date fruit varieties (Phoenix dactylifera L.) as a function of in-vitro simulated gastrointestinal digestion
AU - Kamal, Hina
AU - Hamdi, Marwa
AU - Mudgil, Priti
AU - Aldhaheri, Mouza
AU - Baig, Mohammad Affan
AU - Hassan, Hassan M.
AU - Alamri, Abdulhakeem S.
AU - Galanakis, Charis M.
AU - Maqsood, Sajid
N1 - Funding Information:
The funding of this research by the United Arab Emirates University through a strategic grant (12R055/31R214)to PI 'Sajid Maqsood' is acknowledged. The authors Abdulhakeem S. Alamri and Charis M. Galanakis acknowledge Taif University (TURSP-2020/288, Taif, Saudi Arabia) for their participation.
Funding Information:
The funding of this research by the United Arab Emirates University through a strategic grant ( 12R055/31R214 )to PI 'Sajid Maqsood' is acknowledged. The authors Abdulhakeem S. Alamri and Charis M. Galanakis acknowledge Taif University ( TURSP-2020/288 , Taif, Saudi Arabia) for their participation.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/1/20
Y1 - 2023/1/20
N2 - The present study aims to investigate the digestive process (gastric and intestinal phases) effects on the survivability of total and individual phenolic compounds, and the in vitro health-related bioactive properties of four high-quality and commonly consumed dates (Phoenix dactylifera) varieties (Safawi, Khalas, Khudri, and Booman). Phenolic compounds were analyzed by HPLC-UV (at 275 nm) and a higher amount of phenolics were identified in Khalas and Booman intestinal digested extracts, compared to the other date varieties-based extracts, which corroborates with the total phenolic contents in those samples, with respective values of 186.5 and 358.14 mg GAE/100 g. Considering their bioactive potentialities, the highest DPPH radical scavenging activities, of around 320 TEAC µg/mL, were observed with Khalas and Khudri gastric extracts. In contrast, Khalas intestinal extract displayed the highest ABTS radical scavenging potential of 969 TEAC µg/mL. Moreover, the Safawi intestinal extract, along with Khalas and Booman gastric extracts, showed the highest increase in the α-glucosidase inhibition activity, compared to the other date varieties-based extracts. Safawi and Khalas intestinal extracts displayed the highest DPP-IV inhibition activities (IC50 of 2.85 µg/mL). Additionally, regarding the pancreatic lipase and cholesterol esterase inhibition, Khudri and Khalas varieties after intestinal digestion demonstrated the highest activities. These results suggested that the Khalas variety showed more potent bioactive properties than other date varieties, mainly related to the variations in the phenolic content between date varieties. Overall, this study provides additional insight into investigating these dates varieties upon their simulated gastro-intestinal digestion and exhibition of multifunctional bioactive properties.
AB - The present study aims to investigate the digestive process (gastric and intestinal phases) effects on the survivability of total and individual phenolic compounds, and the in vitro health-related bioactive properties of four high-quality and commonly consumed dates (Phoenix dactylifera) varieties (Safawi, Khalas, Khudri, and Booman). Phenolic compounds were analyzed by HPLC-UV (at 275 nm) and a higher amount of phenolics were identified in Khalas and Booman intestinal digested extracts, compared to the other date varieties-based extracts, which corroborates with the total phenolic contents in those samples, with respective values of 186.5 and 358.14 mg GAE/100 g. Considering their bioactive potentialities, the highest DPPH radical scavenging activities, of around 320 TEAC µg/mL, were observed with Khalas and Khudri gastric extracts. In contrast, Khalas intestinal extract displayed the highest ABTS radical scavenging potential of 969 TEAC µg/mL. Moreover, the Safawi intestinal extract, along with Khalas and Booman gastric extracts, showed the highest increase in the α-glucosidase inhibition activity, compared to the other date varieties-based extracts. Safawi and Khalas intestinal extracts displayed the highest DPP-IV inhibition activities (IC50 of 2.85 µg/mL). Additionally, regarding the pancreatic lipase and cholesterol esterase inhibition, Khudri and Khalas varieties after intestinal digestion demonstrated the highest activities. These results suggested that the Khalas variety showed more potent bioactive properties than other date varieties, mainly related to the variations in the phenolic content between date varieties. Overall, this study provides additional insight into investigating these dates varieties upon their simulated gastro-intestinal digestion and exhibition of multifunctional bioactive properties.
KW - Dates
KW - Health-related bioactivities
KW - High-quality varieties
KW - In vitro gastrointestinal digestion
KW - Phenolic content
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U2 - 10.1016/j.jpba.2022.115113
DO - 10.1016/j.jpba.2022.115113
M3 - Article
C2 - 36327579
AN - SCOPUS:85140923090
SN - 0731-7085
VL - 223
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
M1 - 115113
ER -